M6A Modification: Recent Advances, Anticancer Targeted Drug Discovery and Beyond

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2022 Feb 15

PMID 35164788

Authors

Li-Juan Deng

Wei-Qing Deng

Shu-Ran Fan

Min-Feng Chen

Ming Qi

Wen-Yu Lyu

Qi Qi

Amit K Tiwari

Jia-Xu Chen

Dong-Mei Zhang

Zhe-Sheng Chen

Affiliations

Soon will be listed here.

Abstract

Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets. Both traditional medicine-related approaches and modern drug discovery platforms have been used in an attempt to develop m6A-targeted drugs. Here, we provide an update of the latest findings on m6A modification and the critical roles of m6A modification in cancer progression, and we summarize rational sources for the discovery of m6A-targeted anticancer agents from traditional medicines and computer-based chemosynthetic compounds. This review highlights the potential agents targeting m6A modification for cancer treatment and proposes the advantage of artificial intelligence (AI) in the discovery of m6A-targeting anticancer drugs. Three stages of m6A-targeting anticancer drug discovery: traditional medicine-based natural products, modern chemical modification or synthesis, and artificial intelligence (AI)-assisted approaches for the future.

Citing Articles

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The m6A reader IGF2BP3 promotes HCC progression by enhancing MCM10 stability.

Zhao L, Huang H, Luo L, Huang Z, Wu Z, Wang F Sci Rep. 2025; 15(1):8204.

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