MA-mediated ZNF750 Repression Facilitates Nasopharyngeal Carcinoma Progression

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2018 Dec 7

PMID 30518868

Citations 63

Authors

Panpan Zhang

Qiuping He

Yuan Lei

Yingqin Li

Xin Wen

Mengzhi Hong

Jian Zhang

Xianyue Ren

Yaqin Wang

Xiaojing Yang

Qingmei He

Jun Ma

Na Liu

Affiliations

Soon will be listed here.

Abstract

Nasopharyngeal carcinoma (NPC) progression is regulated by genetic, epigenetic, and epitranscript modulation. As one of the epitranscript modifications, the role of N6-Methyladenosine (mA) has not been elucidated in NPC. In the present study, we found that the poorly methylated gene ZNF750 (encoding zinc finger protein 750) was downregulated in NPC tumor tissues and cell lines. Ectopic expression of ZNF750 blocked NPC growth in vitro and in vivo. Further studies revealed that mA modifications maintained the low expression level of ZNF750 in NPC. Chromatin immunoprecipitation sequencing identified that ZNF750 directly regulated FGF14 (encoding fibroblast growth factor 14), ablation of which reversed ZNF750's tumor repressor effect. Moreover, the ZNF750-FGF14 signaling axis inhibited NPC growth by promoting cell apoptosis. These findings uncovered the critical role of mA in NPC, and stressed the regulatory function of the ZNF750-FGF14 signaling axis in modulating NPC progression, which provides theoretical guidance for the clinical treatment of NPC.

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