Cellular Niches for Hematopoietic Stem Cells and Lympho-Hematopoiesis in Bone Marrow During Homeostasis and Blood Cancers

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2021 Dec 1

PMID 34850281

Citations 3

Authors

Yoshiki Omatsu

Kei Higaki

Takashi Nagasawa

Affiliations

Soon will be listed here.

Abstract

Most types of blood cells, including immune cells are generated from hematopoietic stem cells (HSCs) within bone marrow in the adult. Most HSCs are in contact with and require the special microenvironment known as a niche for their maintenance. It has been thought that HSC niches comprise various types of support cells that provide critical signals, including cytokines and extracellular matrix for HSC regulation. However, among these cells, several lines of evidence have demonstrated that the population of bone marrow-specific mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, which overlap strongly with leptin receptor-expressing (LepR) cells, is the major cellular component of HSC niches. CAR/LepR cells give rise to most adipocytes and osteoblasts in adult bone marrow and express much higher levels of HSC niche factors, including cytokines CXCL12 and stem cell factor (SCF), which are essential for HSC maintenance, and transcription factors Foxc1 and Ebf3, which are essential for the formation and maintenance of HSC niches than other types of cells. CAR/LepR cells are present in human bone marrow, undergo fibrotic expansion, and have reduced expression of HSC niche factors in hematopoietic malignancies.

Citing Articles

From Marrow to Bone and Fat: Exploring the Multifaceted Roles of Leptin Receptor Positive Bone Marrow Mesenchymal Stromal Cells.

Prasad P, Cancelas J Cells. 2024; 13(11.

PMID: 38891042 PMC: 11171870. DOI: 10.3390/cells13110910.

Ebf3 niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.

Nakatani T, Sugiyama T, Omatsu Y, Watanabe H, Kondoh G, Nagasawa T Nat Commun. 2023; 14(1):6402.

PMID: 37880234 PMC: 10600098. DOI: 10.1038/s41467-023-42047-2.

Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions.

Omatsu Y Inflamm Regen. 2023; 43(1):15.

PMID: 36805714 PMC: 9942337. DOI: 10.1186/s41232-023-00267-5.

References

Ara T, Tokoyoda K, Sugiyama T, Egawa T, Kawabata K, Nagasawa T . Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity. 2003; 19(2):257-67. DOI: 10.1016/s1074-7613(03)00201-2. View

Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K . Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004; 118(2):149-61. DOI: 10.1016/j.cell.2004.07.004. View

Barker J . Sl/Sld hematopoietic progenitors are deficient in situ. Exp Hematol. 1994; 22(2):174-7. View

Barker N, van Es J, Kuipers J, Kujala P, van den Born M, Cozijnsen M . Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007; 449(7165):1003-7. DOI: 10.1038/nature06196. View

Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M . Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood. 2014; 124(9):1393-403. PMC: 4148762. DOI: 10.1182/blood-2014-04-570762. View

Bowers M, Zhang B, Ho Y, Agarwal P, Chen C, Bhatia R . Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development. Blood. 2015; 125(17):2678-88. PMC: 4408292. DOI: 10.1182/blood-2014-06-582924. View

Bruns I, Lucas D, Pinho S, Ahmed J, Lambert M, Kunisaki Y . Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med. 2014; 20(11):1315-20. PMC: 4258871. DOI: 10.1038/nm.3707. View

Calvi L, Adams G, Weibrecht K, Weber J, Olson D, Knight M . Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003; 425(6960):841-6. DOI: 10.1038/nature02040. View

Cattoretti G, Schiro R, Orazi A, Soligo D, Colombo M . Bone marrow stroma in humans: anti-nerve growth factor receptor antibodies selectively stain reticular cells in vivo and in vitro. Blood. 1993; 81(7):1726-38. View

10.

Christodoulou C, Spencer J, Yeh S, Turcotte R, Kokkaliaris K, Panero R . Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. 2020; 578(7794):278-283. PMC: 7021587. DOI: 10.1038/s41586-020-1971-z. View

11.

Churchman S, Ponchel F, Boxall S, Cuthbert R, Kouroupis D, Roshdy T . Transcriptional profile of native CD271+ multipotential stromal cells: evidence for multiple fates, with prominent osteogenic and Wnt pathway signaling activity. Arthritis Rheum. 2012; 64(8):2632-43. DOI: 10.1002/art.34434. View

12.

Comazzetto S, Murphy M, Berto S, Jeffery E, Zhao Z, Morrison S . Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow. Cell Stem Cell. 2019; 24(3):477-486.e6. PMC: 6813769. DOI: 10.1016/j.stem.2018.11.022. View

13.

Crozatier M, Ubeda J, Vincent A, Meister M . Cellular immune response to parasitization in Drosophila requires the EBF orthologue collier. PLoS Biol. 2004; 2(8):E196. PMC: 509289. DOI: 10.1371/journal.pbio.0020196. View

14.

DE BRUYN P, Breen P, THOMAS T . The microcirculation of the bone marrow. Anat Rec. 1970; 168(1):55-68. DOI: 10.1002/ar.1091680105. View

15.

Decker M, Leslie J, Liu Q, Ding L . Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance. Science. 2018; 360(6384):106-110. PMC: 5930357. DOI: 10.1126/science.aap8861. View

16.

Degirmenci B, Valenta T, Dimitrieva S, Hausmann G, Basler K . GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Nature. 2018; 558(7710):449-453. DOI: 10.1038/s41586-018-0190-3. View

17.

Dexter T, ALLEN T, LAJTHA L . Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol. 1977; 91(3):335-44. DOI: 10.1002/jcp.1040910303. View

18.

Ding L, Morrison S . Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013; 495(7440):231-5. PMC: 3600153. DOI: 10.1038/nature11885. View

19.

Ding L, Saunders T, Enikolopov G, Morrison S . Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012; 481(7382):457-62. PMC: 3270376. DOI: 10.1038/nature10783. View

20.

Durand A, Donahue B, Peignon G, Letourneur F, Cagnard N, Slomianny C . Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc Natl Acad Sci U S A. 2012; 109(23):8965-70. PMC: 3384132. DOI: 10.1073/pnas.1201652109. View