Hepatic Thrombopoietin is Required for Bone Marrow Hematopoietic Stem Cell Maintenance

Overview

Journal Science

Specialty Science

Date 2018 Apr 7

PMID 29622652

Citations 67

Authors

Matthew Decker

Juliana Leslie

Qingxue Liu

Lei Ding

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cell (HSC) maintenance depends on extrinsic cues. Currently, only local signals arising from the bone marrow niche have been shown to maintain HSCs. However, it is not known whether systemic factors also sustain HSCs. We assessed the physiological source of thrombopoietin (TPO), a key cytokine required for maintaining HSCs. Using knock-in mice, we showed that TPO is expressed by hepatocytes but not by bone marrow cells. Deletion of from hematopoietic cells, osteoblasts, or bone marrow mesenchymal stromal cells does not affect HSC number or function. However, when is deleted from hepatocytes, bone marrow HSCs are depleted. Thus, a cross-organ factor, circulating TPO made in the liver by hepatocytes, is required for bone marrow HSC maintenance. Our results demonstrate that systemic factors, in addition to the local niche, are a critical extrinsic component for HSC maintenance.

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