Takashi Nagasawa
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Explore the profile of Takashi Nagasawa including associated specialties, affiliations and a list of published articles.
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156
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9156
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Recent Articles
1.
Ono M, Tosa I, Dang A, Wang Z, Kimura M, Kitagawa W, et al.
Blood Adv
. 2025 Mar;
PMID: 40080674
Ectopic bone marrow (eBM) holds tremendous potential as an artificial organ, serving not only in stem cell transplantation therapies but also as a controlled experimental system for analyzing cellular dynamics...
2.
Nakatani T, Nagasawa T
Exp Hematol
. 2025 Feb;
144:104749.
PMID: 39978750
Among various types of candidate cells, including osteoblasts and Nestin periarteriolar cells, several lines of histological and genetic evidence have demonstrated that the single population of mesenchymal stem cells, termed...
3.
Yagita-Sakamaki M, Ito T, Sakaguchi T, Shimma S, Li B, Okuzaki D, et al.
Int Immunol
. 2025 Jan;
37(4):235-250.
PMID: 39774647
Several mesenchymal cell populations are known to regulate intestinal stem cell (ISC) self-renewal and differentiation. However, the influences of signaling mediators derived from mesenchymal cells other than ISC niche factors...
4.
Lee M, Matsuo-Dapaah J, Del Rosario Zorrilla C, Omatsu Y, Nagasawa T, Uemura S, et al.
Int Immunol
. 2024 Mar;
36(7):339-352.
PMID: 38430523
Bone marrow is a dynamic organ composed of stem cells that constantly receive signals from stromal cells and other hematopoietic cells in the niches of the bone marrow to maintain...
5.
Kurokawa S, Nomura K, Hosogane N, Nagasawa T, Kawade Y, Matsumoto Y, et al.
J Med Internet Res
. 2024 Feb;
26:e51749.
PMID: 38373022
Background: Given the global shortage of child psychiatrists and barriers to specialized care, remote assessment is a promising alternative for diagnosing and managing attention-deficit/hyperactivity disorder (ADHD). However, only a few...
6.
Nakatani T, Sugiyama T, Omatsu Y, Watanabe H, Kondoh G, Nagasawa T
Nat Commun
. 2023 Oct;
14(1):6402.
PMID: 37880234
Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors. Here, we show that in mice whose CXC...
7.
Abe S, Asahi T, Hara T, Cui G, Shimba A, Tani-Ichi S, et al.
Cell Rep
. 2023 Sep;
42(9):113127.
PMID: 37729919
Natural killer (NK) cells are innate immune cells critical for protective immune responses against infection and cancer. Although NK cells differentiate in the bone marrow (BM) in an interleukin-15 (IL-15)-dependent...
8.
Wu J, Moriwaki K, Asuka T, Nakai R, Kanda S, Taniguchi M, et al.
Blood Adv
. 2023 Apr;
7(14):3382-3394.
PMID: 37042948
Cell polarity, the asymmetric distribution of proteins and organelles, is permanently or transiently established in various cell types and plays an important role in many physiological events. epidermal growth factor...
9.
Anderson N, Sheth V, Li H, Harris M, Qiu S, Crossman D, et al.
Leukemia
. 2022 Dec;
37(3):560-570.
PMID: 36550214
Fms-like tyrosine kinase 3 (Flt3) tyrosine kinase inhibitors (Flt3-TKI) have improved outcomes for patients with Flt3-mutated acute myeloid leukemia (AML) but are limited by resistance and relapse, indicating persistence of...
10.
Kotani H, Masuda N, Yamashita T, Naito Y, Taira T, Inoue K, et al.
Breast Cancer
. 2022 Jul;
29(6):1088-1098.
PMID: 35907135
Background: Talazoparib, a poly(ADP-ribose) polymerase enzyme inhibitor, is approved for the treatment of patients with germline BRCA1/2 (gBRCA1/2)-mutated HER2-negative advanced breast cancer. This two-part study, a recently published dose-escalation part...