Adaptive Homeostasis and the P53 Isoform Network

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2021 Nov 15

PMID 34779563

Citations 21

Authors

Sunali Mehta

Hamish Campbell

Catherine J Drummond

Kunyu Li

Kaisha Murray

Tania Slatter

Jean-Christophe Bourdon

Antony W Braithwaite

Affiliations

Soon will be listed here.

Abstract

All living organisms have developed processes to sense and address environmental changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour suppressor maintains cell and organ integrity and functions in response to homeostasis disruptors (stresses) such as infection, metabolic alterations and cellular damage. Thus, p53 plays a fundamental physiological role in maintaining organismal homeostasis. The TP53 gene encodes a network of proteins (p53 isoforms) with similar and distinct biochemical functions. The p53 network carries out multiple biological activities enabling cooperation between individual cells required for long-term survival of multicellular organisms (animals) in response to an ever-changing environment caused by mutation, infection, metabolic alteration or damage. In this review, we suggest that the p53 network has evolved as an adaptive response to pathogen infections and other environmental selection pressures.

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