Long Noncoding RNAs (lncRNAs) in HIV-mediated Carcinogenesis: Role in Cell Homeostasis, Cell Survival Processes and Drug Resistance

Overview

Journal Noncoding RNA Res

Date 2022 Aug 22

PMID 35991514

Authors

Lilian Makgoo

Salerwe Mosebi

Zukile Mbita

Affiliations

Soon will be listed here.

Abstract

There is accruing data implicating long non-coding RNAs (lncRNAs) in the development and progression of non-communicable diseases such as cancer. These lncRNAs have been implicated in many diverse HIV-host interactions, some of which are beneficial to HIV propagation. The virus-host interactions induce the expression of HIV-regulated long non-coding RNAs, which are implicated in the carcinogenesis process, therefore, it is critical to understand the molecular mechanisms that underpin these HIV-regulated lncRNAs, especially in cancer formation. Herein, we summarize the role of HIV-regulated lncRNAs targeting cancer development-related processes including apoptosis, cell cycle, cell survival signalling, angiogenesis and drug resistance. It is unclear how lncRNAs regulate cancer development, this review also discuss recent discoveries regarding the functions of lncRNAs in cancer biology. Innovative research in this field will be beneficial for the future development of therapeutic strategies targeting long non-coding RNAs that are regulated by HIV, especially in HIV associated cancers.

Citing Articles

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Swanson E, Basting C, Klatt N Microbiome. 2024; 12(1):254.

PMID: 39627860 PMC: 11613800. DOI: 10.1186/s40168-024-01953-3.

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