Influenza A Viruses Control Expression of Proviral Human P53 Isoforms P53β and Delta133p53α

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 Jun 1

PMID 22647703

Citations 23

Authors

Olivier Terrier

Virginie Marcel

Gaelle Cartet

David P Lane

Bruno Lina

Manuel Rosa-Calatrava

Jean-Christophe Bourdon

Affiliations

Soon will be listed here.

Abstract

Previous studies have described the role of p53 isoforms, including p53β and Δ133p53α, in the modulation of the activity of full-length p53, which regulates cell fate. In the context of influenza virus infection, an interplay between influenza viruses and p53 has been described, with p53 being involved in the antiviral response. However, the role of physiological p53 isoforms has never been explored in this context. Here, we demonstrate that p53 isoforms play a role in influenza A virus infection by using silencing and transient expression strategies in human lung epithelial cells. In addition, with the help of a panel of different influenza viruses from different subtypes, we also show that infection differentially regulates the expressions of p53β and Δ133p53α. Altogether, our results highlight the role of p53 isoforms in the viral cycle of influenza A viruses, with p53β and Δ133p53α acting as regulators of viral production in a p53-dependent manner.

Citing Articles

Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis.

Jesus A, Taha A, Wang D, Mehta P, Mehta S, Reily-Bell A Int J Mol Sci. 2023; 24(2).

PMID: 36674782 PMC: 9866425. DOI: 10.3390/ijms24021267.

How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity.

Lamotte L, Tafforeau L Viruses. 2021; 13(11).

PMID: 34835115 PMC: 8619935. DOI: 10.3390/v13112309.

Adaptive homeostasis and the p53 isoform network.

Mehta S, Campbell H, Drummond C, Li K, Murray K, Slatter T EMBO Rep. 2021; 22(12):e53085.

PMID: 34779563 PMC: 8647153. DOI: 10.15252/embr.202153085.

Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells.

Arsic N, Slatter T, Gadea G, Villain E, Fournet A, Kazantseva M Nat Commun. 2021; 12(1):5463.

PMID: 34526502 PMC: 8443592. DOI: 10.1038/s41467-021-25550-2.

The Balance between p53 Isoforms Modulates the Efficiency of HIV-1 Infection in Macrophages.

Breton Y, Barat C, Tremblay M J Virol. 2021; 95(20):e0118821.

PMID: 34379507 PMC: 8475534. DOI: 10.1128/JVI.01188-21.

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