Copper-Catalyzed Oxidative C(sp)-H/C(sp)-H Cross-Coupling Reaction of 3-Methylbenzo[]isoxazoles with Methyl Ketones: Access to Indigoid Analogues
Overview
Overview
Journal
J Org Chem
Publisher
American Chemical Society
Specialty
Chemistry
Date
2021 Nov 5
PMID
34739234
Authors
Affiliations
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Abstract
A copper-catalyzed oxidative C(sp)-H/C(sp)-H cross-coupling reaction of methyl ketones and 3-methylbenzo[]isoxazoles has been developed for the direct synthesis of 3-oxoindolin-2-ylidene derivatives. This process involves an intermolecular nucleophilic addition/ring-opening/aza-Michael addition cascade, providing indigoid analogues with high atom economy and as single isomers exclusively under mild conditions.