Targeting MicroRNA for Improved Skin Health

Overview

Journal Health Sci Rep

Specialty General Medicine

Date 2021 Oct 20

PMID 34667882

Citations 15

Authors

Xi Li

Sakthi Ponandai-Srinivasan

Kutty Selva Nandakumar

Susanne Fabre

Ning Xu Landen

Alain Mavon

Ia Khmaladze

Affiliations

Soon will be listed here.

Abstract

Background: In human skin, miRNAs have important regulatory roles and are involved in the development, morphogenesis, and maintenance by influencing cell proliferation, differentiation, immune regulation, and wound healing. MiRNAs have been investigated for many years in various skin disorders such as atopic dermatitis, psoriasis, as well as malignant tumors. Only during recent times, cosmeceutical use of molecules/natural active ingredients to regulate miRNA expression for significant advances in skin health/care product development was recognized.

Aim: To review miRNAs with the potential to maintain and boost skin health and avoid premature aging by improving barrier function, preventing photoaging, hyperpigmentation, and chronological aging/senescence.

Methods: Most of the cited articles were found through literature search on PubMed. The main search criteria was a keyword "skin" in combination with the following words: miRNA, photoaging, UV, barrier, aging, exposome, acne, wound healing, pigmentation, pollution, and senescence. Most of the articles reviewed for relevancy were published during the past 10 years.

Results: All results are summarized in Figure 1, and they are based on cited references.

Conclusions: Thus, regulating miRNAs expression is a promising approach for novel therapy not only for targeting skin diseases but also for cosmeceutical interventions aiming to boost skin health.

Citing Articles

Study on the Regulatory Mechanisms of Carapace Marking Formation in .

Wang P, Zhu J, Chen H, Hu Q, Chen Z, Li W Animals (Basel). 2025; 15(5).

PMID: 40076010 PMC: 11899420. DOI: 10.3390/ani15050727.

Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology.

Shirley S, Watson A, Yusuf N Int J Mol Sci. 2024; 25(18).

PMID: 39337637 PMC: 11431851. DOI: 10.3390/ijms251810152.

Research Progress in Skin Aging and Immunity.

He X, Gao X, Xie W Int J Mol Sci. 2024; 25(7).

PMID: 38612909 PMC: 11012511. DOI: 10.3390/ijms25074101.

Exploration of altered miRNA expression and function in MSC-derived extracellular vesicles in response to hydatid antigen stimulation.

Wang X, Mijiti W, Jia Q, Yi Z, Ma J, Zhou Z Front Microbiol. 2024; 15:1381012.

PMID: 38601938 PMC: 11004373. DOI: 10.3389/fmicb.2024.1381012.

The Dawning of a New Enterprise: RNA Therapeutics for the Skin.

Kieser R, Khan S, Bejar N, Kiss D J Dermatol Skin Sci. 2024; 5(1):4-13.

PMID: 38435714 PMC: 10907068. DOI: 10.29245/2767-5092/2023/1.1168.

References

Guo J, Zhang J, Wang W, Cheung F, Lu Y, Ng C . MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expression. RNA Biol. 2014; 11(6):732-41. PMC: 4156504. DOI: 10.4161/rna.28865. View

Xu J, Wu W, Zhang L, Dorset-Martin W, Morris M, Mitchell M . The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment. Diabetes. 2012; 61(11):2906-12. PMC: 3478555. DOI: 10.2337/db12-0145. View

Syed D, Imran Khan M, Shabbir M, Mukhtar H . MicroRNAs in skin response to UV radiation. Curr Drug Targets. 2013; 14(10):1128-34. PMC: 3985496. DOI: 10.2174/13894501113149990184. View

Dynoodt P, Mestdagh P, Van Peer G, Vandesompele J, Goossens K, Peelman L . Identification of miR-145 as a key regulator of the pigmentary process. J Invest Dermatol. 2012; 133(1):201-9. DOI: 10.1038/jid.2012.266. View

Han Z, Chen Y, Zhang Y, Wei A, Zhou J, Li Q . MiR-21/PTEN Axis Promotes Skin Wound Healing by Dendritic Cells Enhancement. J Cell Biochem. 2017; 118(10):3511-3519. DOI: 10.1002/jcb.26026. View

Ghosh K, Capell B . The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging. J Invest Dermatol. 2016; 136(11):2133-2139. PMC: 5526201. DOI: 10.1016/j.jid.2016.06.621. View

Smith-Vikos T, Slack F . MicroRNAs and their roles in aging. J Cell Sci. 2012; 125(Pt 1):7-17. PMC: 3269020. DOI: 10.1242/jcs.099200. View

Rock K, Tigges J, Sass S, Schutze A, Florea A, Fender A . miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging. J Invest Dermatol. 2014; 135(2):369-377. DOI: 10.1038/jid.2014.422. View

Jian Q, An Q, Zhu D, Hui K, Liu Y, Chi S . MicroRNA 340 is involved in UVB-induced dendrite formation through the regulation of RhoA expression in melanocytes. Mol Cell Biol. 2014; 34(18):3407-20. PMC: 4135612. DOI: 10.1128/MCB.00106-14. View

10.

Liu Y, Xue L, Gao H, Chang L, Yu X, Zhu Z . Exosomal miRNA derived from keratinocytes regulates pigmentation in melanocytes. J Dermatol Sci. 2019; 93(3):159-167. DOI: 10.1016/j.jdermsci.2019.02.001. View

11.

Shi Q, Zhang W, Guo S, Jian Z, Li S, Li K . Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo. Cell Death Differ. 2015; 23(3):496-508. PMC: 5072443. DOI: 10.1038/cdd.2015.117. View

12.

Van Rooij E, Kauppinen S . Development of microRNA therapeutics is coming of age. EMBO Mol Med. 2014; 6(7):851-64. PMC: 4119351. DOI: 10.15252/emmm.201100899. View

13.

Zhou Z, Shu B, Xu Y, Liu J, Wang P, Chen L . microRNA-203 Modulates Wound Healing and Scar Formation via Suppressing Hes1 Expression in Epidermal Stem Cells. Cell Physiol Biochem. 2018; 49(6):2333-2347. DOI: 10.1159/000493834. View

14.

Mimeault M, Batra S . Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. J Cell Mol Med. 2009; 14(1-2):116-34. PMC: 2916233. DOI: 10.1111/j.1582-4934.2009.00885.x. View

15.

Clark A, Saric S, Sivamani R . Acne Scars: How Do We Grade Them?. Am J Clin Dermatol. 2017; 19(2):139-144. DOI: 10.1007/s40257-017-0321-x. View

16.

Kaidbey K, Agin P, Sayre R, Kligman A . Photoprotection by melanin--a comparison of black and Caucasian skin. J Am Acad Dermatol. 1979; 1(3):249-60. DOI: 10.1016/s0190-9622(79)70018-1. View

17.

Sonkoly E, Stahle M, Pivarcsi A . MicroRNAs: novel regulators in skin inflammation. Clin Exp Dermatol. 2008; 33(3):312-5. DOI: 10.1111/j.1365-2230.2008.02804.x. View

18.

Singhvi G, Manchanda P, Rapalli V, Dubey S, Gupta G, Dua K . MicroRNAs as biological regulators in skin disorders. Biomed Pharmacother. 2018; 108:996-1004. DOI: 10.1016/j.biopha.2018.09.090. View

19.

Serre C, Busuttil V, Botto J . Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation. Int J Cosmet Sci. 2018; 40(4):328-347. DOI: 10.1111/ics.12466. View

20.

Waaijer M, Parish W, Strongitharm B, van Heemst D, Slagboom P, de Craen A . The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell. 2012; 11(4):722-5. PMC: 3539756. DOI: 10.1111/j.1474-9726.2012.00837.x. View