The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2016 Aug 22

PMID 27543988

Citations 67

Authors

Kanad Ghosh

Brian C Capell

Affiliations

Soon will be listed here.

Abstract

Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged cells. However, through the secretion of an array of diverse cytokines, chemokines, growth factors, and proteases known as the senescence-associated secretory phenotype (SASP), senescent cells can paradoxically promote carcinogenesis. Consistent with this, removal of senescent cells delays the onset of cancer and prolongs lifespan in vivo, potentially in part through SASP reduction. In this review, we consider the evidence for the SASP and "SASP-like" inflammation in driving skin carcinogenesis, emphasizing how further understanding of both the roles and mechanisms of SASP expression may offer new targets for skin cancer prevention and therapy.

Citing Articles

The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches.

Burdusel D, Doeppner T, Surugiu R, Hermann D, Olaru D, Popa-Wagner A Biomolecules. 2025; 15(1).

PMID: 39858413 PMC: 11762397. DOI: 10.3390/biom15010018.

The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics.

Balaraman A, Altamimi A, Babu M, Goyal K, Padmapriya G, Bansal P Biogerontology. 2025; 26(1):46.

PMID: 39832057 DOI: 10.1007/s10522-025-10190-6.

Identification and mechanistic insights of cell senescence-related genes in psoriasis.

Deng G, Xu C, Mo D PeerJ. 2025; 13():e18818.

PMID: 39830966 PMC: 11740738. DOI: 10.7717/peerj.18818.

Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics.

Venkataraman A, Kordic I, Li J, Zhang N, Bharadwaj N, Fang Z NPJ Aging. 2024; 10(1):57.

PMID: 39592596 PMC: 11599402. DOI: 10.1038/s41514-024-00178-w.

Proteomic and secretomic comparison of young and aged dermal fibroblasts highlights cytoskeleton as a key component during aging.

Boismal F, Peltier S, Ly Ka So S, Chevreux G, Blondel L, Serror K Aging (Albany NY). 2024; 16(16):11776-11795.

PMID: 39197170 PMC: 11386920. DOI: 10.18632/aging.206055.

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