Therapeutic Efficacy of Artificial Skin Produced by 3D Bioprinting

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2021 Sep 28

PMID 34576409

Citations 9

Authors

Kwang-Sik Jang

Soon-Jung Park

Jong-Jin Choi

Ha-Na Kim

Kyung-Mi Shim

Mi-Jeong Kim

Il-Ho Jang

Song-Wan Jin

Seong-Soo Kang

Se-Eun Kim

Sung-Hwan Moon

Affiliations

Soon will be listed here.

Abstract

The skin protects the body from external barriers. Certain limitations exist in the development of technologies to rapidly prepare skin substitutes that are therapeutically effective in surgeries involving extensive burns and skin transplantation. Herein, we fabricated a structure similar to the skin layer by using skin-derived decellularized extracellular matrix (dECM) with bioink, keratinocytes, and fibroblasts using 3D-printing technology. The therapeutic effects of the produced skin were analyzed using a chimney model that mimicked the human wound-healing process. The 3D-printed skin substitutes exhibited rapid re-epithelialization and superior tissue regeneration effects compared to the control group. These results are expected to aid the development of technologies that can provide customized skin-replacement tissues produced easily and quickly via 3D-printing technology to patients.

Citing Articles

Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration.

Derman I, Rivera T, Garriga Cerda L, Singh Y, Saini S, Abaci H Int J Extrem Manuf. 2024; 7(1):012009.

PMID: 39569402 PMC: 11574952. DOI: 10.1088/2631-7990/ad878c.

Sculpting the future: A narrative review of 3D printing in plastic surgery and prosthetic devices.

Zahid M, Mavani P, Awuah W, Alabdulrahman M, Punukollu R, Kundu A Health Sci Rep. 2024; 7(6):e2205.

PMID: 38915353 PMC: 11194296. DOI: 10.1002/hsr2.2205.

Hydrogel-mediated extracellular vesicles for enhanced wound healing: the latest progress, and their prospects for 3D bioprinting.

Zheng Y, Pan C, Xu P, Liu K J Nanobiotechnology. 2024; 22(1):57.

PMID: 38341585 PMC: 10858484. DOI: 10.1186/s12951-024-02315-9.

Functional materials of 3D bioprinting for wound dressings and skin tissue engineering applications: A review.

Fang H, Xu J, Ma H, Liu J, Xing E, Cheng Y Int J Bioprint. 2023; 9(5):757.

PMID: 37457938 PMC: 10339425.

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings.

Ahmad N Pharmaceutics. 2023; 15(1).

PMID: 36678671 PMC: 9864730. DOI: 10.3390/pharmaceutics15010042.

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