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Bioprinting of Skin Constructs for Wound Healing

Overview
Journal Burns Trauma
Date 2018 Feb 7
PMID 29404374
Citations 68
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Abstract

Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy. Here, we summarize strategies of bioprinting and review current advances of bioprinting of skin constructs. There will be challenges on the way of 3D bioprinting for skin regeneration, but we still believe bioprinting will be potential skills for wounds healing in the foreseeable future.

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References
1.
Lee V, Kim D, Ngo H, Lee Y, Seo L, Yoo S . Creating perfused functional vascular channels using 3D bio-printing technology. Biomaterials. 2014; 35(28):8092-102. PMC: 4112057. DOI: 10.1016/j.biomaterials.2014.05.083. View

2.
Hakkarainen T, Koivuniemi R, Kosonen M, Escobedo-Lucea C, Sanz-Garcia A, Vuola J . Nanofibrillar cellulose wound dressing in skin graft donor site treatment. J Control Release. 2016; 244(Pt B):292-301. DOI: 10.1016/j.jconrel.2016.07.053. View

3.
Nordli H, Chinga-Carrasco G, Rokstad A, Pukstad B . Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells. Carbohydr Polym. 2016; 150:65-73. DOI: 10.1016/j.carbpol.2016.04.094. View

4.
Biedermann T, Boettcher-Haberzeth S, Reichmann E . Tissue engineering of skin for wound coverage. Eur J Pediatr Surg. 2013; 23(5):375-82. DOI: 10.1055/s-0033-1352529. View

5.
Huang R, Li W, Lv X, Lei Z, Bian Y, Deng H . Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing. Biomaterials. 2015; 53:58-75. DOI: 10.1016/j.biomaterials.2015.02.076. View