Magic and Mystery of MicroRNA-32

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2021 Aug 18

PMID 34405957

Citations 8

Authors

Z L Zeng

Qingyun Zhu

Zhibo Zhao

Xuyu Zu

Jianghua Liu

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are a group of endogenous, small (∼22 nts in length) noncoding RNA molecules that function specifically by base pairing with the mRNA of genes and regulate gene expression at the post-transcriptional level. Alterations in miR-32 expression have been found in numerous diseases and shown to play a vital role in cell proliferation, apoptosis, oncogenesis, invasion, metastasis and drug resistance. MiR-32 has been documented as an oncomiR in the majority of related studies but has been also verified as a tumour suppressor miRNA in conflicting reports. Moreover, it has a crucial role in metabolic and cardiovascular disorders. This review provides an in-depth look into the most recent finding regarding miR-32, which is involved in the expression, regulation and functions in different diseases, especially tumours. Additionally, this review outlines novel findings suggesting that miR-32 may be useful as a noninvasive biomarker and as a targeted therapeutic in several diseases.

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