Development of MiRNA-based Therapeutic Approaches for Cancer Patients

Overview

Journal Cancer Sci

Specialty Oncology

Date 2019 Feb 8

PMID 30729639

Citations 65

Authors

Ryou-U Takahashi

Marta Prieto-Vila

Isaku Kohama

Takahiro Ochiya

Affiliations

Soon will be listed here.

Abstract

Over the past few decades, siRNA and miRNA have attracted a great deal of attention from researchers and clinicians. These molecules have been extensively studied from the standpoint of developing biopharmaceuticals against various diseases, including heart disease, diabetes and cancers. siRNA suppresses only a single target, whereas each miRNA regulates the expression of multiple target genes. More importantly, because miRNA are also secreted from cancer cells, and their aberrant expression is associated with tumor development and progression, they represent not only therapeutic targets but also promising biomarkers for diagnosis and prognosis. Therefore, miRNA may be more effective tools against cancers, in which multiple signal pathways are dysregulated. In this review, we summarize recent progress in the development of miRNA therapeutics for the treatment of cancer patients, and describe delivery systems for oligonucleotide therapeutics.

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