From A to MA: The Emerging Viral Epitranscriptome

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Jul 2

PMID 34205979

Citations 28

Authors

Belinda Baquero-Perez

Daryl Geers

Juana Diez

Affiliations

Soon will be listed here.

Abstract

There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. -methyladenosine (mA) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that mA modifications play important roles in regulating viral replication by interacting with the cellular mA machinery. In this review, we will exhaustively detail the current knowledge on mA modification, with an emphasis on its function in virus biology.

Citing Articles

Transcriptome-wide dynamics of mA methylation in ISKNV and Siniperca chuatsi cells infected with ISKNV.

Miao Q, Jiang J, Huang S, Gao J, Liu Q, Zheng R BMC Genomics. 2025; 26(1):22.

PMID: 39789424 PMC: 11714987. DOI: 10.1186/s12864-025-11211-x.

Ramifications of m6A Modification on ncRNAs in Cancer.

Mehmood R Curr Genomics. 2024; 25(3):158-170.

PMID: 39087001 PMC: 11288162. DOI: 10.2174/0113892029296712240405053201.

Elucidation of the Epitranscriptomic RNA Modification Landscape of Chikungunya Virus.

Baquero-Perez B, Bortoletto E, Rosani U, Delgado-Tejedor A, Medina R, Novoa E Viruses. 2024; 16(6).

PMID: 38932237 PMC: 11209572. DOI: 10.3390/v16060945.

Recent insights into N-methyladenosine during viral infection.

Horner S, Reaves J Curr Opin Genet Dev. 2024; 87:102213.

PMID: 38901100 PMC: 11317213. DOI: 10.1016/j.gde.2024.102213.

Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific mAs.

Baek A, Lee G, Golconda S, Rayhan A, Manganaris A, Chen S Nat Microbiol. 2024; 9(5):1340-1355.

PMID: 38605174 PMC: 11087264. DOI: 10.1038/s41564-024-01638-5.

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