Recent Insights Into N-methyladenosine During Viral Infection

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 2024 Jun 20

PMID 38901100

Authors

Stacy M Horner

Jordan V Reaves

Affiliations

Soon will be listed here.

Abstract

The RNA modification of N-methyladenosine (mA) controls many aspects of RNA function that impact biological processes, including viral infection. In this review, we highlight recent work that shapes our current understanding of the diverse mechanisms by which mA can regulate viral infection by acting on viral or cellular mRNA molecules. We focus on emerging concepts and understanding, including how viral infection alters the localization and function of mA machinery proteins, how mA regulates antiviral innate immunity, and the multiple roles of mA in regulating specific viral infections. We also summarize the recent studies on mA during SARS-CoV-2 infection, focusing on points of convergence and divergence. Ultimately, this review provides a snapshot of the latest research on mA during viral infection.

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