Strategies to Study the Functions of Pseudogenes in Mouse Models of Cancer

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2021 Jun 24

PMID 34165722

Citations 1

Authors

Ilah Bok

Florian A Karreth

Affiliations

Soon will be listed here.

Abstract

Aberrant expression of pseudogenes has been observed in many cancer types. Deregulated pseudogenes engage in a multitude of biological processes at the DNA, RNA, and protein levels and eventually facilitate disease progression. To investigate pseudogene functions in cancer, cell lines and cell line transplantation models have been widely used. However, cancer biology is best studied in the context of an intact organism. Here, we present various strategies to investigate pseudogenes in genetically engineered mouse models and discuss advantages and disadvantages of the different approaches.

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