Florian A Karreth
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Explore the profile of Florian A Karreth including associated specialties, affiliations and a list of published articles.
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46
Citations
3273
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Recent Articles
1.
Nowicka Z, Rentzeperis F, Tagal V, Teer J, Ilter D, Beck R, et al.
Cancer Res
. 2025 Feb;
PMID: 39933186
Glioblastoma (GBM) is the most aggressive form of primary brain tumor. The infiltrative nature of GBM makes complete surgical resection impossible. The selective forces that govern gliomagenesis are strong, shaping...
2.
Chadourne M, Griffith C, Xu X, Brennan E, Vera O, Mecozzi N, et al.
bioRxiv
. 2025 Jan;
PMID: 39764055
Thousands of regulatory noncoding RNAs (ncRNAs) have been annotated; however, their functions in gene regulation and contributions to cancer formation remain poorly understood. To gain a better understanding of the...
3.
Jasani N, Xu X, Posorske B, Kim Y, Wang K, Vera O, et al.
Cancer Res
. 2024 Nov;
85(2):314-328.
PMID: 39495254
Overexpression of phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in the serine synthesis pathway, promotes melanomagenesis, melanoma cell proliferation, and survival of metastases in serine-low environments such as the brain. Here,...
4.
Vera O, Martinez M, Soto-Vargas Z, Wang K, Xu X, Ruiz-Buceta S, et al.
bioRxiv
. 2024 Sep;
PMID: 39282450
Transcription factor deregulation potently drives melanoma progression by dynamically and reversibly controlling gene expression programs. We previously identified the small MAF family transcription factor MAFG as a putative driver of...
5.
Jasani N, Xu X, Posorske B, Kim Y, Vera O, Tsai K, et al.
bioRxiv
. 2024 Apr;
PMID: 38659816
Overexpression of PHGDH, the rate-limiting enzyme in the serine synthesis pathway, promotes melanomagenesis, melanoma cell proliferation, and survival of metastases in serine-low environments such as the brain. While amplification explains...
6.
Xu X, Bok I, Jasani N, Wang K, Chadourne M, Mecozzi N, et al.
Cancer Res
. 2024 Jan;
84(3):388-404.
PMID: 38193852
Significance: PTEN suppresses melanoma predominantly through its lipid phosphatase function, which when lost, elevates FRA1 levels through AKT/mTOR signaling to promote several aspects of melanomagenesis.
7.
Tasoulas J, Srivastava S, Xu X, Tarasova V, Maniakas A, Karreth F, et al.
Oncogene
. 2023 Jul;
42(35):2593-2609.
PMID: 37474617
The head and neck region is one of the anatomic sites commonly afflicted by cancer, with ~1.5 million new diagnoses reported worldwide in 2020 alone. Remarkable progress has been made...
8.
DeBlasi J, Falzone A, Caldwell S, Prieto-Farigua N, Prigge J, Schmidt E, et al.
Cancer Res
. 2023 Apr;
83(12):1953-1967.
PMID: 37062029
Significance: Stabilization of the transcription factor NRF2 promotes oncogene-driven tumor initiation but blocks tumor progression, indicating distinct, threshold-dependent effects of the KEAP1/NRF2 pathway in different stages of lung tumorigenesis.
9.
Xu X, Wang K, Vera O, Verma A, Jasani N, Bok I, et al.
Cancer Res
. 2022 Sep;
82(17):3016-3031.
PMID: 36052492
Significance: The function of CEP170, NUCKS1, and ZC3H11A mRNAs as competitive endogenous RNAs that sequester tumor suppressor microRNAs underlies the oncogenic activity of chromosome 1q gains.
10.
Mecozzi N, Nenci A, Vera O, Bok I, Falzone A, DeNicola G, et al.
RNA Biol
. 2022 Mar;
19(1):353-363.
PMID: 35289721
Circular RNAs (circRNAs) are a class of non-coding RNAs featuring a covalently closed ring structure formed through backsplicing. circRNAs are broadly expressed and contribute to biological processes through a variety...