Greatly Enhanced Single Particle Fluorescence Detection Using High Refractive Index Liquid-Core Waveguides

Overview

Journal IEEE J Sel Top Quantum Electron

Publisher IEEE

Date 2021 May 17

PMID 33994767

Citations 1

Authors

Gopikrishnan Gopalakrishnan Meena

Joel G Wright Jr

Aaron R Hawkins

Holger Schmidt

Affiliations

Soon will be listed here.

Abstract

High sensitivity and easy integration with microfabrication techniques has made silicon photonics one of the leading technologies used to build biosensors for diagnostic applications. Here we introduce a new silicon dioxide based optofluidic platform having a planar solid-core (SC) waveguide orthogonally intersecting a liquid-core (LC) waveguide with high refractive index ZnI2 salt solution as core. This enables both more uniform collection of particle fluorescence by the core mode and its propagation to an off-chip detector. This approach results in ultra-high sensitivity performance, demonstrated by achieving 8X enhancement in signal-to-noise ratio, a 45x increase in detection efficiency, and a 100x lower detection limit of 80 aM of fluorescent nanobeads. This represents a key step towards an ultrasensitive biosensor system for analyzing pathogens at clinical concentrations.

Citing Articles

Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip.

Meena G, Stambaugh A, Ganjalizadeh V, Stott M, Hawkins A, Schmidt H APL Photonics. 2022; 6(6).

PMID: 35693725 PMC: 9186413. DOI: 10.1063/5.0049735.

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