Quantum Dots in Diagnostics and Detection: Principles and Paradigms

Overview

Journal Analyst

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2014 Apr 29

PMID 24770716

Citations 27

Authors

T R Pisanic 2nd

Y Zhang

T H Wang

Affiliations

Soon will be listed here.

Abstract

Quantum dots are semiconductor nanocrystals that exhibit exceptional optical and electrical behaviors not found in their bulk counterparts. Following seminal work in the development of water-soluble quantum dots in the late 1990's, researchers have sought to develop interesting and novel ways of exploiting the extraordinary properties of quantum dots for biomedical applications. Since that time, over 10,000 articles have been published related to the use of quantum dots in biomedicine, many of which regard their use in detection and diagnostic bioassays. This review presents a didactic overview of fundamental physical phenomena associated with quantum dots and paradigm examples of how these phenomena can and have been readily exploited for manifold uses in nanobiotechnology with a specific focus on their implementation in in vitro diagnostic assays and biodetection.

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References

Sandros M, Gao D, Benson D . A modular nanoparticle-based system for reagentless small molecule biosensing. J Am Chem Soc. 2005; 127(35):12198-9. DOI: 10.1021/ja054166h. View

Goldman E, Clapp A, Anderson G, Uyeda H, Mauro J, Medintz I . Multiplexed toxin analysis using four colors of quantum dot fluororeagents. Anal Chem. 2004; 76(3):684-8. DOI: 10.1021/ac035083r. View

Voura E, Jaiswal J, Mattoussi H, Simon S . Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat Med. 2004; 10(9):993-8. DOI: 10.1038/nm1096. View

Freeman R, Girsh J, Jou A, Ho J, Hug T, Dernedde J . Optical aptasensors for the analysis of the vascular endothelial growth factor (VEGF). Anal Chem. 2012; 84(14):6192-8. DOI: 10.1021/ac3011473. View

Michalet X, Pinaud F, Bentolila L, Tsay J, Doose S, Li J . Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005; 307(5709):538-44. PMC: 1201471. DOI: 10.1126/science.1104274. View

Resch-Genger U, Grabolle M, Cavaliere-Jaricot S, Nitschke R, Nann T . Quantum dots versus organic dyes as fluorescent labels. Nat Methods. 2008; 5(9):763-75. DOI: 10.1038/nmeth.1248. View

Ho F, Hall E . A strand exchange FRET assay for DNA. Biosens Bioelectron. 2004; 20(5):1001-10. DOI: 10.1016/j.bios.2004.06.017. View

Ho Y, Kung M, Yang S, Wang T . Multiplexed hybridization detection with multicolor colocalization of quantum dot nanoprobes. Nano Lett. 2005; 5(9):1693-7. DOI: 10.1021/nl050888v. View

Jie G, Huang H, Sun X, Zhu J . Electrochemiluminescence of CdSe quantum dots for immunosensing of human prealbumin. Biosens Bioelectron. 2008; 23(12):1896-9. DOI: 10.1016/j.bios.2008.02.028. View

10.

Jiang H, Ju H . Enzyme-quantum dots architecture for highly sensitive electrochemiluminescence biosensing of oxidase substrates. Chem Commun (Camb). 2007; (4):404-6. DOI: 10.1039/b616007g. View

11.

Lacoste T, Michalet X, Pinaud F, Chemla D, Alivisatos A, Weiss S . Ultrahigh-resolution multicolor colocalization of single fluorescent probes. Proc Natl Acad Sci U S A. 2000; 97(17):9461-6. PMC: 16886. DOI: 10.1073/pnas.170286097. View

12.

Zhang C, Johnson L . Quantum-dot-based nanosensor for RRE IIB RNA-Rev peptide interaction assay. J Am Chem Soc. 2006; 128(16):5324-5. PMC: 2582526. DOI: 10.1021/ja060537y. View

13.

Patolsky F, Gill R, Weizmann Y, Mokari T, Banin U, Willner I . Lighting-up the dynamics of telomerization and DNA replication by CdSe-ZnS quantum dots. J Am Chem Soc. 2003; 125(46):13918-9. DOI: 10.1021/ja035848c. View

14.

Medintz I, Stewart M, Trammell S, Susumu K, Delehanty J, Mei B . Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing. Nat Mater. 2010; 9(8):676-84. DOI: 10.1038/nmat2811. View

15.

Wang X, Ren X, Kahen K, Hahn M, Rajeswaran M, Maccagnano-Zacher S . Non-blinking semiconductor nanocrystals. Nature. 2009; 459(7247):686-9. DOI: 10.1038/nature08072. View

16.

Ho Y, Chen H, Leong K, Wang T . Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET. J Control Release. 2006; 116(1):83-9. PMC: 1764605. DOI: 10.1016/j.jconrel.2006.09.005. View

17.

Anderson N, Lian T . Ultrafast electron transfer at the molecule-semiconductor nanoparticle interface. Annu Rev Phys Chem. 2005; 56:491-519. DOI: 10.1146/annurev.physchem.55.091602.094347. View

18.

Chen H, Ho Y, Jiang X, Mao H, Wang T, Leong K . Simultaneous Non-invasive Analysis of DNA Condensation and Stability by Two-step QD-FRET. Nano Today. 2010; 4(2):125-134. PMC: 2746678. DOI: 10.1016/j.nantod.2009.02.008. View

19.

Yao H, Zhang Y, Xiao F, Xia Z, Rao J . Quantum dot/bioluminescence resonance energy transfer based highly sensitive detection of proteases. Angew Chem Int Ed Engl. 2007; 46(23):4346-9. DOI: 10.1002/anie.200700280. View

20.

Xia Z, Xing Y, So M, Koh A, Sinclair R, Rao J . Multiplex detection of protease activity with quantum dot nanosensors prepared by intein-mediated specific bioconjugation. Anal Chem. 2008; 80(22):8649-55. PMC: 2677517. DOI: 10.1021/ac801562f. View