Hematopoietic Stem Cell Heterogeneity is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2021 Apr 2

PMID 33798424

Citations 7

Authors

Jingyuan Tong

Ting Sun

Shihui Ma

Yanhong Zhao

Mankai Ju

Yuchen Gao

Ping Zhu

Puwen Tan

Rongfeng Fu

Anqi Zhang

Ding Wang

Di Wang

Zhijian Xiao

Jiaxi Zhou

Renchi Yang

Stephen J Loughran

Juan Li

Anthony R Green

Emery H Bresnick

Dong Wang

Tao Cheng

Lei Zhang

Lihong Shi

Affiliations

Soon will be listed here.

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Myeloproliferative Neoplasms: Challenging Dogma.

Spivak J J Clin Med. 2024; 13(22).

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Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor.

Guo T, Pei F, Zhang M, Yamada T, Feng J, Jing J Cell Stem Cell. 2024; 31(6):904-920.e6.

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Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity.

Ross J, Myers L, Noh J, Collins M, Carmody A, Messer R Nature. 2024; 628(8006):162-170.

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Clonal architecture evolution in Myeloproliferative Neoplasms: from a driver mutation to a complex heterogeneous mutational and phenotypic landscape.

Maslah N, Benajiba L, Giraudier S, Kiladjian J, Cassinat B Leukemia. 2023; 37(5):957-963.

PMID: 37002477 PMC: 10169637. DOI: 10.1038/s41375-023-01886-0.

References

Pertea M, Kim D, Pertea G, Leek J, Salzberg S . Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown. Nat Protoc. 2016; 11(9):1650-67. PMC: 5032908. DOI: 10.1038/nprot.2016.095. View

Li J, Kent D, Godfrey A, Manning H, Nangalia J, Aziz A . JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease. Blood. 2014; 123(20):3139-51. DOI: 10.1182/blood-2013-06-510222. View

Ortmann C, Kent D, Nangalia J, Silber Y, Wedge D, Grinfeld J . Effect of mutation order on myeloproliferative neoplasms. N Engl J Med. 2015; 372(7):601-612. PMC: 4660033. DOI: 10.1056/NEJMoa1412098. View

Pronk C, Rossi D, Mansson R, Attema J, Norddahl G, Chan C . Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell. 2008; 1(4):428-42. DOI: 10.1016/j.stem.2007.07.005. View

Subramanian A, Tamayo P, Mootha V, Mukherjee S, Ebert B, Gillette M . Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005; 102(43):15545-50. PMC: 1239896. DOI: 10.1073/pnas.0506580102. View

Hao S, Chen C, Cheng T . Cell cycle regulation of hematopoietic stem or progenitor cells. Int J Hematol. 2016; 103(5):487-97. DOI: 10.1007/s12185-016-1984-4. View

Xie M, Lu C, Wang J, McLellan M, Johnson K, Wendl M . Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med. 2014; 20(12):1472-8. PMC: 4313872. DOI: 10.1038/nm.3733. View

Yilmaz O, Valdez R, Theisen B, Guo W, Ferguson D, Wu H . Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092):475-82. DOI: 10.1038/nature04703. View

Kralovics R, Passamonti F, Buser A, Teo S, Tiedt R, Passweg J . A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005; 352(17):1779-90. DOI: 10.1056/NEJMoa051113. View

10.

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H . Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell. 2015; 17(4):422-34. DOI: 10.1016/j.stem.2015.07.007. View

11.

Baxter E, Scott L, Campbell P, East C, Fourouclas N, Swanton S . Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005; 365(9464):1054-61. DOI: 10.1016/S0140-6736(05)71142-9. View

12.

Koschmieder S, Mughal T, Hasselbalch H, Barosi G, Valent P, Kiladjian J . Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both. Leukemia. 2016; 30(5):1018-24. DOI: 10.1038/leu.2016.12. View

13.

James C, Ugo V, Le Couedic J, Staerk J, Delhommeau F, Lacout C . A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005; 434(7037):1144-8. DOI: 10.1038/nature03546. View

14.

Fu R, Liu D, Cao Z, Zhu S, Li H, Su H . Distinct molecular abnormalities underlie unique clinical features of essential thrombocythemia in children. Leukemia. 2015; 30(3):746-9. PMC: 4777775. DOI: 10.1038/leu.2015.167. View

15.

Mullally A, Bruedigam C, Poveromo L, Heidel F, Purdon A, Vu T . Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood. 2013; 121(18):3692-702. PMC: 3643767. DOI: 10.1182/blood-2012-05-432989. View

16.

Genovese G, Kahler A, Handsaker R, Lindberg J, Rose S, Bakhoum S . Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014; 371(26):2477-87. PMC: 4290021. DOI: 10.1056/NEJMoa1409405. View

17.

Li J, Spensberger D, Ahn J, Anand S, Beer P, Ghevaert C . JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood. 2010; 116(9):1528-38. PMC: 3145111. DOI: 10.1182/blood-2009-12-259747. View

18.

Zhang Y, Zhang J, An W, Wan Y, Ma S, Yin J . Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation. Nucleic Acids Res. 2017; 45(2):657-671. PMC: 5314798. DOI: 10.1093/nar/gkw901. View

19.

Verovskaya E, Dellorusso P, Passegue E . Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation. Trends Mol Med. 2019; 25(6):494-515. PMC: 7657013. DOI: 10.1016/j.molmed.2019.04.006. View

20.

Wang X, Dong F, Zhang S, Yang W, Yu W, Wang Z . TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells. Stem Cell Reports. 2018; 11(1):274-287. PMC: 6067088. DOI: 10.1016/j.stemcr.2018.05.017. View