Versatility of Megakaryocytes in Homeostasis and Disease

Overview

Journal Blood Sci

Date 2024 Dec 2

PMID 39620204

Authors

Daosong Wang

Jiayi Xie

Meng Zhao

Affiliations

Soon will be listed here.

Abstract

Megakaryocytes (MKs) constitute a small portion of bone marrow cells and are primarily responsible for producing platelets, which are essential for hemostasis and wound healing. Recent studies have revealed that MKs and platelets perform diverse functions in various physiological and pathological contexts. This comprehensive review highlights the functional diversity of MKs beyond thrombopoiesis, including their roles in regulating hematopoietic stem cells, modulating immune responses, contributing to hematological malignancies, and influencing aging processes.

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