Stephen J Loughran
Overview
Explore the profile of Stephen J Loughran including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
411
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0
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Recent Articles
1.
Mansell E, Lin D, Loughran S, Milsom M, Trowbridge J
Exp Hematol
. 2023 Jul;
125-126:1-5.
PMID: 37433369
Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory...
2.
Bennett C, Jackson V, Pettikiriarachchi A, Hayman T, Schaeper U, Moir-Meyer G, et al.
Blood
. 2023 Mar;
141(26):3199-3214.
PMID: 36928379
Polycythemia vera (PV) is a myeloproliferative neoplasm driven by activating mutations in JAK2 that result in unrestrained erythrocyte production, increasing patients' hematocrit and hemoglobin concentrations, placing them at risk of...
3.
Malouf C, Loughran S, Wilkinson A, Shimamura A, Rio P
Exp Hematol
. 2021 Nov;
105:18-21.
PMID: 34801643
Bone marrow failure syndromes encompass a range of inherited and acquired hematological diseases that result in insufficient blood cell production, which leads to severe complications including anemia, weakening of the...
4.
Tong J, Sun T, Ma S, Zhao Y, Ju M, Gao Y, et al.
Cell Stem Cell
. 2021 Apr;
28(4):780.
PMID: 33798424
No abstract available.
5.
Tong J, Sun T, Ma S, Zhao Y, Ju M, Gao Y, et al.
Cell Stem Cell
. 2021 Feb;
28(3):502-513.e6.
PMID: 33621485
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse phenotypes,...
6.
Loughran S, Haas S, Wilkinson A, Klein A, Brand M
Exp Hematol
. 2020 Jul;
88:1-6.
PMID: 32653531
Blood production is essential to maintain human health, and even small perturbations in hematopoiesis can cause disease. Hematopoiesis has therefore been the focus of much research for many years. Experiments...
7.
Loughran S, Comoglio F, Hamey F, Giustacchini A, Errami Y, Earp E, et al.
J Exp Med
. 2017 Sep;
214(10):3085-3104.
PMID: 28899870
Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin...
8.
Luc S, Luis T, Boukarabila H, Macaulay I, Buza-Vidas N, Bouriez-Jones T, et al.
Nat Immunol
. 2012 Feb;
13(4):412-9.
PMID: 22344248
The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during...
9.
Ng A, Loughran S, Metcalf D, Hyland C, de Graaf C, Hu Y, et al.
Blood
. 2011 Jun;
118(9):2454-61.
PMID: 21673349
Hematopoietic stem cells (HSCs) are rare residents of the bone marrow responsible for the lifelong production of blood cells. Regulation of the balance between HSC self-renewal and differentiation is central...
10.
Ng A, Hyland C, Metcalf D, Carmichael C, Loughran S, Di Rago L, et al.
Blood
. 2009 Dec;
115(19):3966-9.
PMID: 20007548
Down syndrome is characterized by multiple phenotypic manifestations associated with trisomy of chromosome 21. The transient myeloproliferative disorder and acute megakaryocytic leukemia associated with Down syndrome are uniquely associated with...