Nanostructured Biomaterials for Models of Bone Metastasis Cancer

Overview

Journal Curr Opin Biomed Eng

Specialty Biomedical Engineering

Date 2021 Mar 15

PMID 33718691

Citations 7

Authors

Kalpana S Katti

Haneesh Jasuja

Sumanta Kar

Dinesh R Katti

Affiliations

Soon will be listed here.

Abstract

In recent years, tissue engineering approaches have attracted substantial attention owing to their ability to create physiologically relevant disease models that closely mimic conditions. Here, we review nanocomposite materials and scaffolds used for the design of models of cancer, including metastatic sites. We discuss the role of material properties in modulating cellular phenotype in 3D disease models. Also, we highlight the application of tissue-engineered bone as a tool for faithful recapitulation of the microenvironment of metastatic prostate and breast cancer, since these two types of cancer have the propensity to metastasize to bone. Overall, we summarize recent efforts on developing 3D models of bone metastatic cancers that provide a platform to study tumor progression and facilitate high-throughput drug screening.

Citing Articles

Review of Spider Silk Applications in Biomedical and Tissue Engineering.

Brankovic M, Zivic F, Grujovic N, Stojadinovic I, Milenkovic S, Kotorcevic N Biomimetics (Basel). 2024; 9(3).

PMID: 38534854 PMC: 10967872. DOI: 10.3390/biomimetics9030169.

The Variety of 3D Breast Cancer Models for the Study of Tumor Physiology and Drug Screening.

Frohlich E Int J Mol Sci. 2023; 24(8).

PMID: 37108283 PMC: 10139112. DOI: 10.3390/ijms24087116.

Prostate cancer bone metastases biology and clinical management (Review).

Goode E, Wang N, Munkley J Oncol Lett. 2023; 25(4):163.

PMID: 36960185 PMC: 10028493. DOI: 10.3892/ol.2023.13749.

Interstitial fluid flow contributes to prostate cancer invasion and migration to bone; study conducted using a novel horizontal flow bioreactor.

Jasuja H, Jaswandkar S, Katti D, Katti K Biofabrication. 2023; 15(2).

PMID: 36863017 PMC: 10020972. DOI: 10.1088/1758-5090/acc09a.

Nanoclays in medicine: a new frontier of an ancient medical practice.

Katti K, Jasuja H, Jaswandkar S, Mohanty S, Katti D Mater Adv. 2022; 3(20):7484-7500.

PMID: 36324871 PMC: 9577303. DOI: 10.1039/d2ma00528j.

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