Nanotechnological Strategies for Engineering Complex Tissues

Overview

Journal Nat Nanotechnol

Specialty Biotechnology

Date 2010 Dec 15

PMID 21151110

Citations 339

Authors

Tal Dvir

Brian P Timko

Daniel S Kohane

Robert Langer

Affiliations

Soon will be listed here.

Abstract

Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.

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