Persistent Cellular Immunity to SARS-CoV-2 Infection

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2021 Feb 3

PMID 33533915

Citations 85

Authors

Gaelle Breton

Pilar Mendoza

Thomas Hagglof

Thiago Y Oliveira

Dennis Schaefer-Babajew

Christian Gaebler

Martina Turroja

Arlene Hurley

Marina Caskey

Michel C Nussenzweig

Affiliations

Soon will be listed here.

Abstract

SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen-specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4+ and CD8+ memory T cells, including expression of activation/exhaustion markers, and cell division.

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