Development of the Facial Glycation Imaging System for in Situ Human Face Skin Glycation Index Measurement

Overview

Journal J Cosmet Dermatol

Specialty Dermatology

Date 2021 Feb 1

PMID 33522691

Citations 4

Authors

Jinyong Lee

Eui Taek Jeong

Jun-Man Lim

Sun Gyoo Park

Affiliations

Soon will be listed here.

Abstract

Background: The accumulation of advanced glycation end products has been proposed as a causative agent of skin aging, but there are no conventional devices for quantifying advanced glycation end-product accumulation in facial skin.

Aims: This study aimed to develop a convenient and accurate in situ advanced glycation end-product measurement system for the human face.

Methods: We developed a facial glycation imaging system, which consisted of illumination (white light-emitting diode, ultraviolet light-emitting diode) and image acquisition modules to capture face images. Advanced glycation end product-related autofluorescence and total skin reflectance were calculated to obtain the skin glycation index using an image analysis algorithm. Correlations between the skin glycation index and facial skin elasticity and age were examined in 36 healthy Korean women.

Results: The facial glycation imaging system was validated against a volar forearm skin autofluorescence measurement device, that is, the AGE Reader mu, with forearm skin glycation index (R = 0.64, P < .01). Cheek elasticity was negatively correlated with cheek skin glycation index (R = -0.56, R = -0.57, and R = -0.61, P < .01 for R2, R5, and R7, respectively). Age was significantly correlated with forearm skin glycation index (R = 0.44, P < .01) and cheek skin glycation index (R = 0.48, P < .01).

Conclusion: We successfully developed a novel in situ facial skin glycation index measurement device. Our convenient and accurate system enables in situ skin glycation index monitoring for skin aging studies such as those on anti-glycation cosmetics.

Citing Articles

Reversing Glycation with a Dietary Supplement Containing Rosemary Extract.

Draelos Z, Bucay V, Watchmaker J, Valacchi G J Clin Aesthet Dermatol. 2025; 18(2):44-49.

PMID: 40078862 PMC: 11896625.

Advanced Glycation End Products and Health: A Systematic Review.

Zhu J, Wang Z, Lv C, Li M, Wang K, Chen Z Ann Biomed Eng. 2024; 52(12):3145-3156.

PMID: 38705931 DOI: 10.1007/s10439-024-03499-9.

Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors.

Zheng W, Li H, Go Y, Chan X, Huang Q, Wu J Nutrients. 2022; 14(21).

PMID: 36364850 PMC: 9655929. DOI: 10.3390/nu14214588.

Advanced Glycation End Products in the Skin: Molecular Mechanisms, Methods of Measurement, and Inhibitory Pathways.

Chen C, Zhang J, Li L, Guo M, He Y, Dong Y Front Med (Lausanne). 2022; 9:837222.

PMID: 35646963 PMC: 9131003. DOI: 10.3389/fmed.2022.837222.

Development of the facial glycation imaging system for in situ human face skin glycation index measurement.

Lee J, Jeong E, Lim J, Park S J Cosmet Dermatol. 2021; 20(9):2963-2968.

PMID: 33522691 PMC: 8451778. DOI: 10.1111/jocd.13943.

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