Advanced Glycation End Products and Health: A Systematic Review

Overview

Journal Ann Biomed Eng

Specialty Biomedical Engineering

Date 2024 May 5

PMID 38705931

Authors

Jianming Zhu

Ziming Wang

Chunyan Lv

Mengtian Li

Kaiyi Wang

Zhencheng Chen

Affiliations

Soon will be listed here.

Abstract

Advanced glycation end products (AGEs) have garnered significant attention due to their association with chronic diseases and the aging process. The prevalence of geriatric diseases among young individuals has witnessed a notable surge in recent years, potentially attributed to the accelerated pace of modern life. The accumulation of AGEs is primarily attributed to their inherent difficulty in metabolism, which makes them promising biomarkers for chronic disease detection. This review aims to provide a comprehensive overview of the recent advancements and findings in AGE research. The discussion is divided into two main sections: endogenous AGEs (formed within the body) and exogenous AGEs (derived from external sources). Various aspects of AGEs are subsequently summarized, including their production pathways, pathogenic mechanisms, and detection methods. Moreover, this review delves into the future research prospects concerning AGEs. Overall, this comprehensive review underscores the importance of AGEs in the detection of chronic diseases and provides a thorough understanding of their significance. It emphasizes the necessity for further research endeavors to deepen our comprehension of AGEs and their implications for human health.

Citing Articles

Cardamonin Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis Through Promoting STAT3 Signaling.

Yang T, Wu P, Jiang L, Chen R, Jin Q, Ye G J Inflamm Res. 2024; 17:8861-8879.

PMID: 39569022 PMC: 11577436. DOI: 10.2147/JIR.S486412.

Phytochemical Composition and Functional Properties of Brassicaceae Microgreens: Impact of In Vitro Digestion.

Sola I, Vujcic Bok V, Popovic M, Gagic S Int J Mol Sci. 2024; 25(21).

PMID: 39519385 PMC: 11546364. DOI: 10.3390/ijms252111831.

Nuclear Factor-Kappa-B Mediates the Advanced Glycation End Product-Induced Repression of Gene Expression in 3T3-L1 Adipocytes.

Michalani M, Passarelli M, Machado U Int J Mol Sci. 2024; 25(15).

PMID: 39125811 PMC: 11311564. DOI: 10.3390/ijms25158242.

Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage.

Luo Y, Fujiwara-Tani R, Kawahara I, Goto K, Nukaga S, Nishida R Int J Mol Sci. 2024; 25(13).

PMID: 39000167 PMC: 11241065. DOI: 10.3390/ijms25137060.

References

Grillo M, Colombatto S . Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases. Amino Acids. 2007; 35(1):29-36. DOI: 10.1007/s00726-007-0606-0. View

Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T . Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem. 2001; 276(17):13935-40. DOI: 10.1074/jbc.M010677200. View

Chen G, Smith J . Determination of advanced glycation endproducts in cooked meat products. Food Chem. 2014; 168:190-5. DOI: 10.1016/j.foodchem.2014.06.081. View

Kislinger T, Humeny A, Pischetsrieder M . Analysis of protein glycation products by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Curr Med Chem. 2004; 11(16):2185-93. DOI: 10.2174/0929867043364649. View

Birlouez-Aragon I, Saavedra G, Tessier F, Galinier A, Ait-Ameur L, Lacoste F . A diet based on high-heat-treated foods promotes risk factors for diabetes mellitus and cardiovascular diseases. Am J Clin Nutr. 2010; 91(5):1220-6. DOI: 10.3945/ajcn.2009.28737. View

Harcourt B, Sourris K, Coughlan M, Walker K, Dougherty S, Andrikopoulos S . Targeted reduction of advanced glycation improves renal function in obesity. Kidney Int. 2011; 80(2):190-8. DOI: 10.1038/ki.2011.57. View

Takeuchi M, Takino J, Yamagishi S . Involvement of the toxic AGEs (TAGE)-RAGE system in the pathogenesis of diabetic vascular complications: a novel therapeutic strategy. Curr Drug Targets. 2010; 11(11):1468-82. DOI: 10.2174/1389450111009011468. View

Wang Z, Jiang Y, Liu N, Ren L, Zhu Y, An Y . Advanced glycation end-product Nε-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes. Atherosclerosis. 2012; 221(2):387-96. DOI: 10.1016/j.atherosclerosis.2012.01.019. View

Liu S, Sheu W, Lee M, Lee W, Yi Y, Yang T . Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation. J Pathol. 2012; 230(2):215-27. DOI: 10.1002/path.4045. View

10.

Prasad C, Davis K, Imrhan V, Juma S, Vijayagopal P . Advanced Glycation End Products and Risks for Chronic Diseases: Intervening Through Lifestyle Modification. Am J Lifestyle Med. 2019; 13(4):384-404. PMC: 6600625. DOI: 10.1177/1559827617708991. View

11.

Schmidt A, Yan S, Yan S, STERN D . The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest. 2001; 108(7):949-55. PMC: 200958. DOI: 10.1172/JCI14002. View

12.

Luevano-Contreras C, Durkin T, Pauls M, Chapman-Novakofski K . Development, relative validity, and reliability of a food frequency questionnaire for a case-control study on dietary advanced glycation end products and diabetes complications. Int J Food Sci Nutr. 2013; 64(8):1030-5. DOI: 10.3109/09637486.2013.816939. View

13.

Ahmed M, Dunn J, Walla M, Thorpe S, Baynes J . Oxidative degradation of glucose adducts to protein. Formation of 3-(N epsilon-lysino)-lactic acid from model compounds and glycated proteins. J Biol Chem. 1988; 263(18):8816-21. View

14.

Snelson M, Coughlan M . Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology. Nutrients. 2019; 11(2). PMC: 6413015. DOI: 10.3390/nu11020215. View

15.

Feng N, Feng Y, Tan J, Zhou C, Xu J, Chen Y . Inhibition of advance glycation end products formation, gastrointestinal digestion, absorption and toxicity: A comprehensive review. Int J Biol Macromol. 2023; 249:125814. DOI: 10.1016/j.ijbiomac.2023.125814. View

16.

Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R . Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010; 110(6):911-16.e12. PMC: 3704564. DOI: 10.1016/j.jada.2010.03.018. View

17.

Tessier F, Niquet-Leridon C, Jacolot P, Jouquand C, Genin M, Schmidt A . Quantitative assessment of organ distribution of dietary protein-bound C-labeled N -carboxymethyllysine after a chronic oral exposure in mice. Mol Nutr Food Res. 2016; 60(11):2446-2456. DOI: 10.1002/mnfr.201600140. View

18.

Kellow N, Coughlan M, Reid C . Association between habitual dietary and lifestyle behaviours and skin autofluorescence (SAF), a marker of tissue accumulation of advanced glycation endproducts (AGEs), in healthy adults. Eur J Nutr. 2017; 57(6):2209-2216. DOI: 10.1007/s00394-017-1495-y. View

19.

Kellow N, Savige G . Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review. Eur J Clin Nutr. 2013; 67(3):239-48. DOI: 10.1038/ejcn.2012.220. View

20.

Clarke R, Dordevic A, Tan S, Ryan L, Coughlan M . Dietary Advanced Glycation End Products and Risk Factors for Chronic Disease: A Systematic Review of Randomised Controlled Trials. Nutrients. 2016; 8(3):125. PMC: 4808855. DOI: 10.3390/nu8030125. View