The Role of Microbiota in Allogeneic Hematopoietic Stem Cell Transplantation

Overview

Journal Expert Opin Biol Ther

Specialties Biology
Pharmacology

Date 2021 Jan 8

PMID 33412949

Citations 6

Authors

Chia-Chi Chang

Eiko Hayase

Robert R Jenq

Affiliations

Soon will be listed here.

Abstract

Introduction: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is commonly performed to treat a variety of benign and malignant hematological diseases. Acute graft-versus-host disease (GVHD) is a major life-threatening complication that often occurs following allo-HSCT. Recently, improvements in methods to characterize the microbiota have led to a greater appreciation for how frequently and profoundly an alteration in microbial composition, or dysbiosis, can occur in allo-HSCT recipients to better decipher the complex interplay between microbiota and allo-HSCT outcomes.

Areas Covered: This article reviews the current knowledge of the microbiota's impact on allo-HSCT outcomes, including effects of microbiota-derived metabolites, and crosstalk between commensals and the allogeneic immune response. This article also summarizes the effects of HSCT and transplant-related procedures on microbiota, and recent developments in interventional strategies.

Expert Opinion: A growing body of literature indicates that the composition of the intestinal microbiota can function as a predictive biomarker for the risk and severity of acute GVHD, as well as overall survival, in patients undergoing allo-HSCT. Mechanisms underpinning these associations, however, are not well understood, and clinical strategies that modulate the microbiome to improve outcomes have yet to be fully developed. There is an unmet need to determine mechanisms to improve the efficacy of allo-HSCT.

Citing Articles

Advancing therapeutic strategies for graft-versus-host disease by targeting gut microbiome dynamics in allogeneic hematopoietic stem cell transplantation: current evidence and future directions.

Azhar Ud Din M, Lin Y, Lyu C, Yi C, Fang A, Mao F Mol Med. 2025; 31(1):2.

PMID: 39754054 PMC: 11699782. DOI: 10.1186/s10020-024-01060-x.

Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases.

Artacho A, Gonzalez-Torres C, Gomez-Cebrian N, Moles-Poveda P, Pons J, Jimenez N Microbiome. 2024; 12(1):229.

PMID: 39511587 PMC: 11542268. DOI: 10.1186/s40168-024-01948-0.

Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study.

Gavriilaki E, Christoforidi M, Ouranos K, Minti F, Mallouri D, Varelas C Int J Mol Sci. 2024; 25(11).

PMID: 38891979 PMC: 11171546. DOI: 10.3390/ijms25115789.

Longitudinal Changes of Ocular Surface Microbiome in Patients Undergoing Hemopoietic Stem Cell Transplant (HSCT).

Clougher S, Severgnini M, Marangoni A, Consolandi C, Camboni T, Morselli S J Clin Med. 2024; 13(1).

PMID: 38202215 PMC: 10779677. DOI: 10.3390/jcm13010208.

Klebsiella quasipneumoniae in intestine damages bile acid metabolism in hematopoietic stem cell transplantation patients with bloodstream infection.

Yin G, Guo Y, Ding Q, Ma S, Chen F, Wang Q J Transl Med. 2023; 21(1):230.

PMID: 36991414 PMC: 10061697. DOI: 10.1186/s12967-023-04068-9.

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