Oral Microbiomes: More and More Importance in Oral Cavity and Whole Body

Overview

Journal Protein Cell

Publisher Oxford University Press

Specialties Biochemistry
Cell Biology

Date 2018 May 9

PMID 29736705

Citations 317

Authors

Lu Gao

Tiansong Xu

Gang Huang

Song Jiang

Yan Gu

Feng Chen

Affiliations

Soon will be listed here.

Abstract

Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases and systemic diseases. Oral microbiomes play an important role in the human microbial community and human health. The use of recently developed molecular methods has greatly expanded our knowledge of the composition and function of the oral microbiome in health and disease. Studies in oral microbiomes and their interactions with microbiomes in variable body sites and variable health condition are critical in our cognition of our body and how to make effect on human health improvement.

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References

Han Y, Redline R, Li M, Yin L, Hill G, McCormick T . Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun. 2004; 72(4):2272-9. PMC: 375172. DOI: 10.1128/IAI.72.4.2272-2279.2004. View

Cianciola L, Park B, Bruck E, Mosovich L, Genco R . Prevalence of periodontal disease in insulin-dependent diabetes mellitus (juvenile diabetes). J Am Dent Assoc. 1982; 104(5):653-60. DOI: 10.14219/jada.archive.1982.0240. View

Ford A, Moayyedi P, Hanauer S . Ulcerative colitis. BMJ. 2013; 346:f432. DOI: 10.1136/bmj.f432. View

Veloso F . Extraintestinal manifestations of inflammatory bowel disease: do they influence treatment and outcome?. World J Gastroenterol. 2011; 17(22):2702-7. PMC: 3122258. DOI: 10.3748/wjg.v17.i22.2702. View

Chen T, Yu W, Izard J, Baranova O, Lakshmanan A, Dewhirst F . The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database (Oxford). 2010; 2010:baq013. PMC: 2911848. DOI: 10.1093/database/baq013. View

Butler 3rd R, Soomer-James J, Frenette M, Pombert J . Complete Genome Sequences of Two Human Oral Microbiome Commensals, ATCC 25975 and ATCC 27945. Genome Announc. 2017; 5(24). PMC: 5473274. DOI: 10.1128/genomeA.00536-17. View

Ling Z, Liu X, Cheng Y, Jiang X, Jiang H, Wang Y . Decreased Diversity of the Oral Microbiota of Patients with Hepatitis B Virus-Induced Chronic Liver Disease: A Pilot Project. Sci Rep. 2015; 5:17098. PMC: 4660595. DOI: 10.1038/srep17098. View

An J, Darveau R, Kaeberlein M . Oral health in geroscience: animal models and the aging oral cavity. Geroscience. 2017; 40(1):1-10. PMC: 5832657. DOI: 10.1007/s11357-017-0004-9. View

Baumgart M, Dogan B, Rishniw M, Weitzman G, Bosworth B, Yantiss R . Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. ISME J. 2007; 1(5):403-18. DOI: 10.1038/ismej.2007.52. View

10.

Kuczynski J, Lauber C, Walters W, Parfrey L, Clemente J, Gevers D . Experimental and analytical tools for studying the human microbiome. Nat Rev Genet. 2011; 13(1):47-58. PMC: 5119550. DOI: 10.1038/nrg3129. View

11.

Correa J, Calderaro D, Ferreira G, Mendonca S, Fernandes G, Xiao E . Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status. Microbiome. 2017; 5(1):34. PMC: 5359961. DOI: 10.1186/s40168-017-0252-z. View

12.

Raychaudhuri S, Sandor C, Stahl E, Freudenberg J, Lee H, Jia X . Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet. 2012; 44(3):291-6. PMC: 3288335. DOI: 10.1038/ng.1076. View

13.

. 2016 Alzheimer's disease facts and figures. Alzheimers Dement. 2016; 12(4):459-509. DOI: 10.1016/j.jalz.2016.03.001. View

14.

. Structure, function and diversity of the healthy human microbiome. Nature. 2012; 486(7402):207-14. PMC: 3564958. DOI: 10.1038/nature11234. View

15.

Cullinan M, Westerman B, Hamlet S, Palmer J, Faddy M, Lang N . A longitudinal study of interleukin-1 gene polymorphisms and periodontal disease in a general adult population. J Clin Periodontol. 2001; 28(12):1137-44. DOI: 10.1034/j.1600-051x.2001.281208.x. View

16.

Reddy R, Weir W, Barnett S, Heiden B, Orringer M, Lin J . Increased Variance in Oral and Gastric Microbiome Correlates With Esophagectomy Anastomotic Leak. Ann Thorac Surg. 2018; 105(3):865-870. DOI: 10.1016/j.athoracsur.2017.08.061. View

17.

Ma C, Chen F, Zhang Y, Sun X, Tong P, Si Y . Comparison of oral microbial profiles between children with severe early childhood caries and caries-free children using the human oral microbe identification microarray. PLoS One. 2015; 10(3):e0122075. PMC: 4378984. DOI: 10.1371/journal.pone.0122075. View

18.

Lira-Junior R, Bostrom E . Oral-gut connection: one step closer to an integrated view of the gastrointestinal tract?. Mucosal Immunol. 2018; 11(2):316-318. DOI: 10.1038/mi.2017.116. View

19.

Costalonga M, Herzberg M . The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett. 2014; 162(2 Pt A):22-38. PMC: 4346134. DOI: 10.1016/j.imlet.2014.08.017. View

20.

Thorstensson H, Hugoson A . Periodontal disease experience in adult long-duration insulin-dependent diabetics. J Clin Periodontol. 1993; 20(5):352-8. DOI: 10.1111/j.1600-051x.1993.tb00372.x. View