Identify and Validate the Transcriptomic, Functional Network, and Predictive Validity of FBXL19-AS1 in Hepatocellular Carcinoma

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Dec 21

PMID 33344260

Citations 4

Authors

Dingdong He

Xiaokang Zhang

Xinyu Zhu

Narayani Maharjan

Yingchao Wang

Ping Luo

Chunzi Liang

Jiancheng Tu

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common neoplastic diseases worldwide. Available biomarkers are not sensitive enough for the diagnosis of HCC, hence seeking new biomarkers of HCC is urgent and challenging. The purpose of this study was to investigate the role of F-box and leucine-rich repeat protein 19-antisense RNA 1 (FBXL19-AS1) through a functional network and inquire into its diagnostic and prognostic value in HCC. A comprehensive strategy of genomic data mining, bioinformatics and experimental validation was used to evaluate the clinical value of FBXL19-AS1 in the diagnosis and prognosis of HCC and to identify the pathways in which FBXL19-AS1 might be involved. FBXL19-AS1 was up-regulated in HCC tissues, and its high expression was associated with TNM stage and poor prognosis of HCC patients. The combination of FBXL19-AS1 and alpha-fetoprotein (AFP) in plasma could prominently improve the diagnostic validity for HCC. FBXL19-AS1 might stabilize FBXL19 to reduce the amount of macrophage M1, and then promote the occurrence and development of HCC. Meanwhile, FBXL19-AS1 might participate in regulating HCC related pathways through FBXL19-AS1-miRNA-mRNA network. Our findings indicated that FBXL19-AS1 not only serves as a potential biomarker for HCC diagnosis and prognosis, but also might be functionally carcinogenic.

Citing Articles

FLVCR1-AS1 and FBXL19-AS1: Two Putative lncRNA Candidates in Multiple Human Cancers.

Sheykhhasan M, Tanzadehpanah H, Yazdi A, Mahaki H, Seyedebrahimi R, Akbari M Noncoding RNA. 2023; 9(1).

PMID: 36649030 PMC: 9844485. DOI: 10.3390/ncrna9010001.

Long Noncoding RNA FBXL19-AS1-Mediated Ulcerative Colitis-Associated Intestinal Epithelial Barrier Defect.

Zhao X, Cui D, Yang L, Yuan W, Yan F Tissue Eng Regen Med. 2022; 19(5):1077-1088.

PMID: 36048401 PMC: 9478015. DOI: 10.1007/s13770-022-00479-9.

Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases.

Yao Q, Zhang X, Chen D Front Oncol. 2022; 12:848296.

PMID: 35280790 PMC: 8914342. DOI: 10.3389/fonc.2022.848296.

MDM2 Binding Protein Induces the Resistance of Hepatocellular Carcinoma Cells to Molecular Targeting Agents Enhancing the Transcription Factor Activity of the Pregnane X Receptor.

Jiang Q, Ma Y, Han J, Chu J, Ma X, Shen L Front Oncol. 2021; 11:715193.

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