Preoperative Controlling Nutritional Status (CONUT) Score for Assessment of Prognosis Following Hepatectomy for Hepatocellular Carcinoma

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2017 Apr 9

PMID 28389736

Citations 36

Authors

Kosei Takagi

Takahito Yagi

Yuzo Umeda

Susumu Shinoura

Ryuichi Yoshida

Daisuke Nobuoka

Takashi Kuise

Hiroyuki Araki

Toshiyoshi Fujiwara

Affiliations

Soon will be listed here.

Abstract

Background: Immune-nutritional status has been recently reported as a prognostic factor in hepatocellular carcinoma (HCC). The controlling nutritional status (CONUT) score has been established as a useful tool to evaluate immune-nutritional status. This study aimed to investigate the efficacy of the CONUT score as a prognostic factor in patients undergoing hepatectomy for HCC.

Methods: A total of 295 patients who underwent curative hepatectomy for HCC between January 2007 and December 2014 were retrospectively analyzed. Patients were divided into two groups according to the CONUT score. The impact of the CONUT score on clinicopathological, surgical, and long-term outcomes was evaluated. Subsequently, the impact of prognostic factors, including the CONUT score, associated with outcomes was assessed using multivariate analyses.

Results: Of 295 patients, 118 (40%) belonged to the high CONUT group (CONUT score ≥ 3). The high CONUT group had a significantly lower 5-year recurrence-free survival rate than the low CONUT group (27.9 vs. 41.4%, p = 0.011) and a significantly lower 5-year overall survival rate (61.9 vs. 74.9%, p = 0.006). In multivariate analyses of prognostic factors, the CONUT score was an independent predictor of recurrence-free survival (hazard ratio = 1.64, p = 0.006) and overall survival (hazard ratio = 2.50, p = 0.001).

Conclusions: The CONUT score is a valuable preoperative predictor of survival in patients undergoing hepatectomy for HCC.

Citing Articles

Clinical significance of the Naples prognostic score in predicting short- and long-term postoperative outcomes of patients with hepatocellular carcinoma.

Hosoda K, Shimizu A, Kubota K, Notake T, Kitagawa N, Yoshizawa T World J Surg. 2024; 49(2):502-511.

PMID: 39631788 PMC: 11798678. DOI: 10.1002/wjs.12448.

The CONUT score is associated with the pathologic grade in non-small cell lung cancer.

Onodera K, Notsuda H, Watanabe T, Watanabe Y, Suzuki T, Hirama T Surg Today. 2024; 54(12):1437-1444.

PMID: 38709286 PMC: 11582223. DOI: 10.1007/s00595-024-02860-8.

Controlling Nutritional Status (CONUT) Score is Associated with Overall Survival in Patients with Hepatocellular Carcinoma Treated with Conventional Transcatheter Arterial Chemoembolization: A Propensity Score Matched Analysis.

Deng Z, Zhang W, Peng J, Gao L, Zhang C, Lei K Cardiovasc Intervent Radiol. 2024; 47(5):592-603.

PMID: 38605220 DOI: 10.1007/s00270-024-03712-1.

Value of preoperative controlling nutritional status score in prognosis of patients with high-risk factors for early-stage cervical cancer.

Tan F, Xia R, Zeng L, Xie H, Long X, Peng C Pak J Med Sci. 2024; 40(1Part-I):120-127.

PMID: 38196446 PMC: 10772423. DOI: 10.12669/pjms.40.1.7406.

Development of a clinical scoring model to predict the overall and relapse‑free survival of patients with hepatocellular carcinoma following a hepatectomy.

Deng W, Chen F, Li Y, Xu L Mol Clin Oncol. 2023; 19(5):87.

PMID: 37854326 PMC: 10580259. DOI: 10.3892/mco.2023.2683.

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