Biological Implications and Clinical Potential of Metastasis-Related MiRNA in Colorectal Cancer

Overview

Journal Mol Ther Nucleic Acids

Publisher Cell Press

Date 2020 Dec 18

PMID 33335791

Citations 23

Authors

Liaoran Niu

Wanli Yang

Lili Duan

Xiaoqian Wang

Yiding Li

Chengchao Xu

Chao Liu

Yujie Zhang

Wei Zhou

Jinqiang Liu

Qingchuan Zhao

Liu Hong

Daiming Fan

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC), ranking as the third commonest cancer, leads to extremely high rates of mortality. Metastasis is the major cause of poor outcome in CRC. When metastasis occurs, 5-year survival rates of patients decrease sharply, and strategies to enhance a patient's lifetime seem limited. MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that are significantly involved in manipulation of CRC malignant phenotypes, including proliferation, invasion, and metastasis. To date, accumulating studies have revealed the mechanisms and functions of certain miRNAs in CRC metastasis. However, there is no systematic discussion about the biological implications and clinical potential (diagnostic role, prognostic role, and targeted therapy potential) of metastasis-related miRNAs in CRC. This review mainly summarizes the recent advances of miRNA-mediated metastasis in CRC. We also discuss the clinical values of metastasis-related miRNAs as potential biomarkers or therapeutic targets in CRC. Moreover, we envisage the future orientation and challenges in translating these findings into clinical applications.

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