Novel Insights on Perils and Promises of MiRNA in Understanding Colon Cancer Metastasis and Progression

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2023 Aug 28

PMID 37639075

Authors

Lubna Tariq

Azher Arafah

Nouroz Sehar

Aarif Ali

Andleeb Khan

Iyman Rasool

Shahzada Mudasir Rashid

Sheikh Bilal Ahmad

Saba Beigh

Tanveer Ul Hassan Dar

Muneeb U Rehman

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is the third highest frequent malignancy and ultimate critical source of cancer-associated mortality around the world. Regardless of latest advances in molecular and surgical targeted medicines that have increased remedial effects in CRC patients, the 5-year mortality rate for CRC patients remains dismally low. Evidence suggests that microRNAs (miRNAs) execute an essential part in the development and spread of CRC. The miRNAs are a type of short non-coding RNA that exhibited to control the appearance of tumor suppressor genes and oncogenes. miRNA expression profiling is already being utilized in clinical practice as analytical and prognostic biomarkers to evaluate cancer patients' tumor genesis, advancement, and counteraction to drugs. By modulating their target genes, dysregulated miRNAs are linked to malignant characteristics (e.g., improved proliferative and invasive capabilities, cell cycle aberration, evasion of apoptosis, and promotion of angiogenesis). This review presents an updated summary of circulatory miRNAs, tumor-suppressive and oncogenic miRNAs, and the potential reasons for dysregulated miRNAs in CRC. Further we will explore the critical role of miRNAs in CRC drug resistance.

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