Circulating Exosomal MiR-17-5p and MiR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer

Overview

Journal Transl Oncol

Specialty Oncology

Date 2018 Jan 26

PMID 29367070

Citations 114

Authors

Fangfang Fu

Weiqin Jiang

Linfu Zhou

Zhi Chen

Affiliations

Soon will be listed here.

Abstract

Conclusions: Circulating exosomal miR-17-5p and miR-92a-3p may provide a promising noninvasive prognostic biomarker for primary and metastatic CRC.

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References

Kara M, Yumrutas O, Ozcan O, Celik O, Bozgeyik E, Bozgeyik I . Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma. Gene. 2015; 567(1):81-6. DOI: 10.1016/j.gene.2015.04.065. View

Halkein J, Tabruyn S, Ricke-Hoch M, Haghikia A, Nguyen N, Scherr M . MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J Clin Invest. 2013; 123(5):2143-54. PMC: 3638905. DOI: 10.1172/JCI64365. View

Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W . Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015; 527(7576):100-104. PMC: 4819404. DOI: 10.1038/nature15376. View

van Niel G, Raposo G, Candalh C, Boussac M, HERSHBERG R, Cerf-Bensussan N . Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology. 2001; 121(2):337-49. DOI: 10.1053/gast.2001.26263. View

Thery C, Amigorena S, Raposo G, Clayton A . Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2008; Chapter 3:Unit 3.22. DOI: 10.1002/0471143030.cb0322s30. View

Zhou W, Fong M, Min Y, Somlo G, Liu L, Palomares M . Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014; 25(4):501-15. PMC: 4016197. DOI: 10.1016/j.ccr.2014.03.007. View

Zhao K, Liang G, Sun X, Guan L . Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes. BMC Genomics. 2016; 17(1):630. PMC: 4983018. DOI: 10.1186/s12864-016-2962-1. View

Xie J, Fan X, Drummond C, Majumder R, Xie Y, Chen T . MicroRNA profiling in kidney disease: Plasma versus plasma-derived exosomes. Gene. 2017; 627:1-8. PMC: 5534180. DOI: 10.1016/j.gene.2017.06.003. View

Torre L, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J, Jemal A . Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65(2):87-108. DOI: 10.3322/caac.21262. View

10.

Fang L, Li H, Wang L, Hu J, Jin T, Wang J . MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression. Oncotarget. 2014; 5(10):2974-87. PMC: 4102784. DOI: 10.18632/oncotarget.1614. View

11.

Ren P, Gong F, Zhang Y, Jiang J, Zhang H . MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN. Tumour Biol. 2015; 37(3):3215-25. DOI: 10.1007/s13277-015-4150-3. View

12.

Zhu H, Han C, Wu T . MiR-17-92 cluster promotes hepatocarcinogenesis. Carcinogenesis. 2015; 36(10):1213-22. PMC: 4794620. DOI: 10.1093/carcin/bgv112. View

13.

Ji H, Greening D, Barnes T, Lim J, Tauro B, Rai A . Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. Proteomics. 2013; 13(10-11):1672-86. DOI: 10.1002/pmic.201200562. View

14.

Ke T, Wei P, Yeh K, Chen W, Cheng Y . MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway. Ann Surg Oncol. 2014; 22(8):2649-55. DOI: 10.1245/s10434-014-4305-2. View

15.

Olive V, Li Q, He L . mir-17-92: a polycistronic oncomir with pleiotropic functions. Immunol Rev. 2013; 253(1):158-66. PMC: 3972423. DOI: 10.1111/imr.12054. View

16.

Park S, Lee S, Cho H, Kim T, Kim J, Kim J . Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer. Oncotarget. 2016; 7(8):9501-12. PMC: 4891055. DOI: 10.18632/oncotarget.7033. View

17.

Liu Q, Yu Z, Yuan S, Xie W, Li C, Hu Z . Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer. Oncotarget. 2017; 8(8):13048-13058. PMC: 5355076. DOI: 10.18632/oncotarget.14369. View

18.

Zhou X, Wen W, Shan X, Zhu W, Xu J, Guo R . A six-microRNA panel in plasma was identified as a potential biomarker for lung adenocarcinoma diagnosis. Oncotarget. 2016; 8(4):6513-6525. PMC: 5351649. DOI: 10.18632/oncotarget.14311. View

19.

Tang F, Hajkova P, Barton S, Lao K, Surani M . MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res. 2006; 34(2):e9. PMC: 1351374. DOI: 10.1093/nar/gnj009. View

20.

Zhu M, Huang Z, Zhu D, Zhou X, Shan X, Qi L . A panel of microRNA signature in serum for colorectal cancer diagnosis. Oncotarget. 2017; 8(10):17081-17091. PMC: 5370024. DOI: 10.18632/oncotarget.15059. View