Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges

Overview

Journal JACC Basic Transl Sci

Date 2020 Dec 9

PMID 33294743

Citations 23

Authors

Catia A Santos-Ferreira

Monica T Abreu

Carla I Marques

Lino M Goncalves

Rui Baptista

Henrique M Girao

Affiliations

Soon will be listed here.

Abstract

Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the role of miRNAs in PAH is expanding quickly, and it is increasingly difficult to identify which miRNAs have the highest translational potential. This review summarizes the current knowledge of miRNA expression in PAH, discusses the challenges in miRNA analysis and interpretation, and highlights 4 promising miRNAs in this field (miR-29, miR-124, miR-140, and miR-204).

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