Expression and Regulation of HIF-1a in Hypoxic Pulmonary Hypertension: Focus on Pathological Mechanism and Pharmacological Treatment

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2024 Jan 2

PMID 38164358

Authors

Jia-Jing Wan

Jian Yi

Fei-Ying Wang

Chao Zhang

Ai-Guo Dai

Affiliations

Soon will be listed here.

Abstract

Hypoxia inducible factor-1(HIF-1), a heterodimeric transcription factor, is composed of two subunits (HIF-1α and HIF-1β). It is considered as an important transcription factor for regulating oxygen changes in hypoxic environment, which can regulate the expression of various hypoxia-related target genes and play a role in acute and chronic hypoxia pulmonary vascular reactions. In this paper, the function and mechanism of HIF-1a expression and regulation in hypoxic pulmonary hypertension (HPH) were reviewed, and current candidate schemes for treating pulmonary hypertension by using HIF-1a as the target were introduced, so as to provide reference for studying the pathogenesis of HPH and screening effective treatment methods.

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