Microarray Analysis in Pulmonary Hypertension

Overview

Journal Eur Respir J

Specialty Pulmonary Medicine

Date 2016 Apr 15

PMID 27076594

Citations 39

Authors

Julia Hoffmann

Jochen Wilhelm

Andrea Olschewski

Grazyna Kwapiszewska

Affiliations

Soon will be listed here.

Abstract

Microarrays are a powerful and effective tool that allows the detection of genome-wide gene expression differences between controls and disease conditions. They have been broadly applied to investigate the pathobiology of diverse forms of pulmonary hypertension, namely group 1, including patients with idiopathic pulmonary arterial hypertension, and group 3, including pulmonary hypertension associated with chronic lung diseases such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. To date, numerous human microarray studies have been conducted to analyse global (lung homogenate samples), compartment-specific (laser capture microdissection), cell type-specific (isolated primary cells) and circulating cell (peripheral blood) expression profiles. Combined, they provide important information on development, progression and the end-stage disease. In the future, system biology approaches, expression of noncoding RNAs that regulate coding RNAs, and direct comparison between animal models and human disease might be of importance.

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