Building Genomes to Understand Biology

Overview

Journal Nat Commun

Specialty Biology

Date 2020 Dec 3

PMID 33268788

Citations 15

Authors

Alessandro L V Coradini

Cara B Hull

Ian M Ehrenreich

Affiliations

Soon will be listed here.

Abstract

Genetic manipulation is one of the central strategies that biologists use to investigate the molecular underpinnings of life and its diversity. Thus, advances in genetic manipulation usually lead to a deeper understanding of biological systems. During the last decade, the construction of chromosomes, known as synthetic genomics, has emerged as a novel approach to genetic manipulation. By facilitating complex modifications to chromosome content and structure, synthetic genomics opens new opportunities for studying biology through genetic manipulation. Here, we discuss different classes of genetic manipulation that are enabled by synthetic genomics, as well as biological problems they each can help solve.

Citing Articles

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The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.

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The design and engineering of synthetic genomes.

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Building synthetic chromosomes from natural DNA.

Coradini A, Ville C, Krieger Z, Roemer J, Hull C, Yang S Nat Commun. 2023; 14(1):8337.

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