Synthetic Genomics From a Yeast Perspective

Overview

Journal Front Bioeng Biotechnol

Date 2022 Apr 7

PMID 35387293

Authors

Charlotte C Koster

Eline D Postma

Ewout Knibbe

Celine Cleij

Pascale Daran-Lapujade

Affiliations

Soon will be listed here.

Abstract

Synthetic Genomics focuses on the construction of rationally designed chromosomes and genomes and offers novel approaches to study biology and to construct synthetic cell factories. Currently, progress in Synthetic Genomics is hindered by the inability to synthesize DNA molecules longer than a few hundred base pairs, while the size of the smallest genome of a self-replicating cell is several hundred thousand base pairs. Methods to assemble small fragments of DNA into large molecules are therefore required. Remarkably powerful at assembling DNA molecules, the unicellular eukaryote has been pivotal in the establishment of Synthetic Genomics. Instrumental in the assembly of entire genomes of various organisms in the past decade, the genome foundry has a key role to play in future Synthetic Genomics developments.

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