Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography

Overview

Journal IEEE Trans Biomed Eng

Specialties Biomedical Engineering
Biophysics

Date 2020 Nov 11

PMID 33175676

Citations 1

Authors

Ruofei Bu

Santosh Balakrishnan

Nicusor Iftimia

Hillel Price

Carlton Zdanski

Sorin Mitran

Amy L Oldenburg

Affiliations

Soon will be listed here.

Abstract

Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.

Citing Articles

Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].

Leartprapun N, Adie S Biomed Opt Express. 2023; 14(1):208-248.

PMID: 36698669 PMC: 9842001. DOI: 10.1364/BOE.468932.

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