Airway Compliance Measured by Anatomic Optical Coherence Tomography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2017 Jul 25

PMID 28736665

Citations 7

Authors

Ruofei Bu

Santosh Balakrishnan

Nicusor Iftimia

Hillel Price

Carlton Zdanski

Amy L Oldenburg

Affiliations

Soon will be listed here.

Abstract

Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal cross-sectional area (CSA) under physiologically relevant pressures of 10-40 cmHO. The accuracy and precision of CC measurements are determined using simulations of non-uniform rotation distortion (NURD) endemic to endoscopic scanning, and experiments performed in a simplified tube phantom and porcine tracheas. NURD simulations show that CC measurements are typically more accurate than that of the CSAs from which they are derived. Phantom measurements of CSA versus pressure exhibit high linearity (>0.99), validating the dynamic range of the SSaOCT system. Tracheas also exhibited high linearity ( = 0.98) suggestive of linear elasticity, while CC measurements were obtained with typically ± 12% standard error.

Citing Articles

Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].

Leartprapun N, Adie S Biomed Opt Express. 2023; 14(1):208-248.

PMID: 36698669 PMC: 9842001. DOI: 10.1364/BOE.468932.

Graph-based rotational nonuniformity correction for localized compliance measurement in the human nasopharynx.

Miao Y, Jing J, Chen Z Biomed Opt Express. 2021; 12(4):2508-2518.

PMID: 33996244 PMC: 8086476. DOI: 10.1364/BOE.419997.

Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.

Bu R, Balakrishnan S, Iftimia N, Price H, Zdanski C, Mitran S IEEE Trans Biomed Eng. 2020; 68(8):2360-2367.

PMID: 33175676 PMC: 8110609. DOI: 10.1109/TBME.2020.3037288.

Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty.

Balakrishnan S, Bu R, Waters C, Brandon B, Kimbell J, Stepp W J Biomed Opt. 2020; 25(1):1-11.

PMID: 31912688 PMC: 7008596. DOI: 10.1117/1.JBO.25.1.016001.

Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review.

Miao Y, Brenner M, Chen Z Otolaryngol (Sunnyvale). 2019; 9(2).

PMID: 31497378 PMC: 6731096. DOI: 10.4172/2161-119X.1000366.

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