Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 CDCs

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2020 Oct 21

PMID 33086061

Citations 36

Authors

Mattia Gallizioli

Francesc Miro-Mur

Amaia Otxoa-de-Amezaga

Roger Cugota

Angelica Salas-Perdomo

Carles Justicia

Vanessa H Brait

Francisca Ruiz-Jaen

Maria Arbaizar-Rovirosa

Jordi Pedragosa

Ester Bonfill-Teixidor

Mathias Gelderblom

Tim Magnus

Eva Cano

Carlos Del Fresno

David Sancho

Anna M Planas

Affiliations

Soon will be listed here.

Abstract

Brain CD11c cells share features with microglia and dendritic cells (DCs). Sterile inflammation increases brain CD11c cells, but their phenotype, origin, and functions remain largely unknown. We report that, after cerebral ischemia, microglia attract DCs to the inflamed brain, and astroglia produce Flt3 ligand, supporting development and expansion of CD11c cells. CD11c cells in the inflamed brain are a complex population derived from proliferating microglia and infiltrating DCs, including a major subset of OX40L conventional cDC2, and also cDC1, plasmacytoid, and monocyte-derived DCs. Despite sharing certain morphological features and markers, CD11c microglia and DCs display differential expression of pattern recognition receptors and chemokine receptors. DCs excel CD11c and CD11c microglia in the capacity to present antigen through MHCI and MHCII. Of note, cDC1s protect from brain injury after ischemia. We thus reveal aspects of the dynamics and functions of brain DCs in the regulation of inflammation and immunity.

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