Hyperuricemia, the Heart, and the Kidneys - to Treat or Not to Treat?

Overview

Journal Ren Fail

Publisher Informa Healthcare

Date 2020 Sep 25

PMID 32972284

Citations 25

Authors

Tadej Petreski

Robert Ekart

Radovan Hojs

Sebastjan Bevc

Affiliations

Soon will be listed here.

Abstract

Background: Hyperuricemia is a state in which the serum levels of uric acid are elevated. As such it has a pronounced effect on vascular and renal function with their consequences, while also showing some antioxidant effects that show to be beneficial.

Summary: Hyperuricemia has shown to have a J-shaped relationship with mortality, is frequently associated with development and progression of heart and kidney disease, and is correlated with malnutrition-inflammation-atherosclerosis syndrome, although several Mendelian studies have failed to show an association with morbidity and mortality. Hyperuricemia is usually associated with gout flares and tophi development but can also present as asymptomatic hyperuricemia. It is still uncertain whether asymptomatic hyperuricemia is an independent risk factor for cardiovascular or renal disease and as such its treatment is questionable.

Key Messages: Some possible tools for future decision making are the use of noninvasive techniques such as pulse wave analysis, urinary sediment analysis, and joint ultrasound, which could help identify individuals with asymptomatic hyperuricemia that could benefit from urate lowering therapy most.

Citing Articles

Association between RC/HDL-C and hyperuricemia in adults: evidence from NHANES 2005-2018.

Tai Y, Chen B, Kong Y, Wang X Front Endocrinol (Lausanne). 2025; 16:1514067.

PMID: 40065993 PMC: 11891044. DOI: 10.3389/fendo.2025.1514067.

The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.

Zhang J, Sun N, Zhang W, Yue W, Qu X, Li Z Front Endocrinol (Lausanne). 2025; 16:1515176.

PMID: 39968300 PMC: 11832375. DOI: 10.3389/fendo.2025.1515176.

Excess Weight Loss at 6 Months Following Laparoscopic Sleeve Gastrectomy Correlates with the Remission of Hyperuricemia.

Chu Y, Cao C, Shao Y, Hua R, Yao Q Obes Surg. 2025; 35(3):829-836.

PMID: 39810032 DOI: 10.1007/s11695-025-07668-0.

U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study.

Huang J, Mi N, Yang J, Zheng Y, Yuan J, Meng W Front Oncol. 2025; 14:1482814.

PMID: 39763609 PMC: 11700790. DOI: 10.3389/fonc.2024.1482814.

Integrated Data Mining and Animal Experiments to Investigate the Efficacy and Potential Pharmacological Mechanism of a Traditional Tibetan Functional Food . in Hyperuricemia.

Liu W, Zhang M, Tan J, Liu H, Wang L, Liao J J Inflamm Res. 2024; 17:11111-11128.

PMID: 39713714 PMC: 11662633. DOI: 10.2147/JIR.S484987.

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