Preventive Effect of YH1136 Against Uric Acid Accumulation and Renal Damages

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 May 1

PMID 38690361

Authors

Xingting Zhang

Junliang Jiang

Jinge Xin

Ning Sun

Zhifang Zhao

Baoxing Gan

Yi Jiang

Xuemei Gong

Hao Li

Hailin Ma

Xueqin Ni

Yu Chen

Yang Bai

Hesong Wang

Affiliations

Soon will be listed here.

Abstract

Background: Hyperuricemia (HUA) is a prevalent metabolic disorder whose development is associated with intestinal microbiota. Therefore, probiotics have emerged as a potential and safe approach for lowering uric acid (UA) levels. However, the underlying mechanisms of many effective probiotic strains remain unknown.

Methods And Results: C57BL/6 mice were randomly divided into two groups: control and model groups. The model group received 12 weeks of potassium oxonate. Through 16s sequencing we found that HUA resulted in a significant decrease in the total diversity of all intestinal segments. When each intestinal segment was analyzed individually, the reduction in diversity was only significant in the cecum and colon sections. RDA analysis showed that lactobacilli in the rat colon exhibited a strong correlation with model group, suggesting that may play an important role in HUA. Consequently, the preventive effects of YH1136 against HUA were investigated. C57BL/6 mice were randomly divided into three groups: control, model and YH1136 groups. The results showed that administering YH1136 effectively reduced serum UA levels by inhibiting hepatic xanthine oxidase (XOD) activity and promoting renal ABCG2 transporter expression. Moreover, supplementation with YH1136 significantly ameliorated pathological damage in the kidney and liver, thereby reducing UA accumulation.

Conclusion: Hyperuricemia is accompanied by an altered composition of multiple gut bacteria, of which is a key genus. YH1136 may ameliorate renal involvement in HUA via the gut-kidney axis.

Citing Articles

Fucoidan Oligosaccharide Supplementation Relieved Kidney Injury and Modulated Intestinal Homeostasis in D-Galactose-Exposed Rats.

Shi J, Xu Y, Zhang K, Liu Y, Zhang N, Zhang Y Nutrients. 2025; 17(2).

PMID: 39861454 PMC: 11769225. DOI: 10.3390/nu17020325.

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