Efficacy of Biocage in Treating Single-segment Lumbar Degenerative Disease in Patients with High Risk of Non-fusion: a Prospective Controlled Study with at Least 2 Years' Follow-up

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2020 Sep 23

PMID 32962480

Citations 1

Authors

Yang Li

Yang Yu

Tian-Yong Hou

Ze-Hua Zhang

Jun-Chao Xing

Hong-Wei Lu

Rui Zhou

Peng Cheng

Jian-Zhong Xu

Wen-Jie Wu

Fei Luo

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the clinical efficacy of an allogeneic bone cage (Biocage; Beijing Datsing Bio-Tech Co., Ltd., Beijing, China) for treatment of single-segment lumbar degenerative disease in patients with a high risk of non-fusion.

Methods: From January 2013 to December 2016, 67 patients who underwent lumbar fusion were divided into the Biocage group (n = 33) and polyether ether ketone (PEEK) group (n = 34). The patients were followed up for 24 to 48 months. The mean intervertebral height of the fusion level, fusion rate, height of the intervertebral foramen, visual analog scale score, and Oswestry disability index were compared.

Results: The PEEK group had a lower fusion rate than the Biocage group (88.24% vs. 90.91%), although the difference was not statistically significant. During follow-up, the height of the intervertebral space was similar between the Biocage and PEEK groups (12.88 ± 0.45 and 12.84 ± 1.01 mm, respectively). The height of the intervertebral foramen was larger in the Biocage than PEEK group (20.67 ± 1.34 vs. 20.00 ± 2.05 mm). Good clinical efficacy was achieved in both groups.

Conclusion: The Biocage is efficient and safe for treatment of single-segment lumbar degenerative disease in patients with a high risk of non-fusion.

Citing Articles

Allografts and Spinal Fusion.

Cohen J, Kanim L, Tronits A, Bae H Int J Spine Surg. 2021; 15(s1):68-93.

PMID: 34376497 PMC: 8092936. DOI: 10.14444/8056.

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