Mitochondrial Metabolism and Cancer Metastasis

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2020 Aug 15

PMID 32793748

Citations 13

Authors

Dandan Yu

Chang Liu

Ling Guo

Affiliations

Soon will be listed here.

Abstract

Metastasis is regarded as the most important cause of cancer-related deaths around the world. During the complicated metastatic cascade, altered mitochondrial metabolism adapts to serve distinct conditions and microenvironments. In this review, we discuss how cells regulate their mitochondria metabolism to adapt to environmental cues during the metastasis, as well as how cancer cells and their tumor micro-environment (TME) are metabolically coupled during the metastatic cascade. We place a strong emphasis on how mitochondrial proline metabolism and extracellular matrix (ECM) are coupled.

Citing Articles

Chen Y, Zhang J, Zheng W, Xu H PLoS One. 2025; 20(2):e0315927.

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The compartment-specific manipulation of the NAD/NADH ratio affects the metabolome and the function of glioblastoma.

Lee M, Yoo J, Kim I, Kang S, Lee W, Kim S Sci Rep. 2024; 14(1):20575.

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Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge.

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Cuproptosis: unveiling a new frontier in cancer biology and therapeutics.

Feng Y, Yang Z, Wang J, Zhao H Cell Commun Signal. 2024; 22(1):249.

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Regulation of mitochondrial metabolism by autophagy supports leptin-induced cell migration.

Garcia-Miranda A, Montes-Alvarado J, Sarmiento-Salinas F, Vallejo-Ruiz V, Castaneda-Saucedo E, Navarro-Tito N Sci Rep. 2024; 14(1):1408.

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