Kindlin-2 Controls Bidirectional Signaling of Integrins

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2008 May 17

PMID 18483218

Citations 220

Authors

Eloi Montanez

Siegfried Ussar

Martina Schifferer

Michael Bosl

Roy Zent

Markus Moser

Reinhard Fassler

Affiliations

Soon will be listed here.

Abstract

Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling.

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