Tumor Metastasis: Moving New Biological Insights into the Clinic

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2013 Nov 9

PMID 24202397

Citations 376

Authors

Liling Wan

Klaus Pantel

Yibin Kang

Affiliations

Soon will be listed here.

Abstract

As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.

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